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- NCIT_C105813 IAO_0000115 "A human serotype 5, replication-defective, first generation adenoviral vector, with the viral E1a and E3 protein encoding regions deleted, which is engineered to express the soluble, immune-mediated stimulatory gene human fms-like tyrosine kinase 3 ligand (Flt3L), under the transcriptional control of the CMV promoter, with potential immunostimulating activity. Upon administration, Ad-hCMV-Flt3L is transduced into tumor cells and Flt3L is expressed. Flt3L stimulates both the proliferation of dendritic cells (DCs) and their migration to the tumor site. Upon exposure to the tumor-associated antigens (TAA) released from dying glioma cells, which were killed by thymidine kinase-mediated valacyclovir-induced tumor cell death, the DCs initiate a specific immune response against any remaining TAA-expressing tumor cells. Flt3L is a hematopoietic growth factor and ligand for the Flt3 tyrosine kinase receptor." @default.
- NCIT_C105813 NCIT_A7 NCIT_C26202 @default.
- NCIT_C105813 NCIT_NHC0 "C105813" @default.
- NCIT_C105813 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C105813 NCIT_P107 "Ad-hCMV-Flt3L" @default.
- NCIT_C105813 NCIT_P108 "Ad-hCMV-Flt3L" @default.
- NCIT_C105813 NCIT_P208 "CL447164" @default.
- NCIT_C105813 NCIT_P322 "CTRP" @default.
- NCIT_C105813 NCIT_P329 "747933" @default.
- NCIT_C105813 NCIT_P330 "747933" @default.
- NCIT_C105813 NCIT_P399 "747933" @default.
- NCIT_C105813 normalizedInformationContent "100" @default.
- NCIT_C105813 referenceCount "1" @default.
- NCIT_C105813 hasExactSynonym "Ad-hCMV-Flt3L" @default.
- NCIT_C105813 inSubset NCIT_C116977 @default.
- NCIT_C105813 inSubset NCIT_C116978 @default.
- NCIT_C105813 inSubset NCIT_C128784 @default.
- NCIT_C105813 inSubset NCIT_C176424 @default.
- NCIT_C105813 type Class @default.
- NCIT_C105813 isDefinedBy ncit.owl @default.
- NCIT_C105813 label "Ad-hCMV-Flt3L" @default.
- NCIT_C105813 subClassOf NCIT_C105813 @default.
- NCIT_C105813 subClassOf NCIT_C129820 @default.
- NCIT_C105813 subClassOf NCIT_C1908 @default.
- NCIT_C105813 subClassOf NCIT_C1909 @default.
- NCIT_C105813 subClassOf NCIT_C1962 @default.
- NCIT_C105813 subClassOf NCIT_C274 @default.
- NCIT_C105813 subClassOf NCIT_C307 @default.
- NCIT_C105813 subClassOf NCIT_C308 @default.
- NCIT_C105813 subClassOf NCIT_C61199 @default.