Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C105850> ?p ?o ?g. }
Showing items 1 to 34 of
34
with 100 items per page.
- NCIT_C105850 IAO_0000115 "A radioconjugate composed of 2'-deoxy-2'-18F-fluoro-5-methyl-beta-L-arabinofuranosylcytosine ([18F]L-FMAC), a L-deoxycytidine analog and high-affinity substrate for deoxycytidine kinase (DCK), labeled with fluorine F 18, with potential diagnostic activity during positron emission tomography (PET) imaging. Upon administration, [18F]L-FMAC is preferentially taken up by and accumulated in cells with high DCK levels, including tumor cells with dysregulated nucleoside metabolism. After phosphorylation by DCK, the 18F moiety can be visualized by PET imaging. As many nucleoside analog prodrugs are chemotherapeutic agents that require DCK for their phosphorylation and activation, [18F]L-FMAC can potentially be used as a marker to measure DCK activity and to predict the chemotherapeutic efficacy of DCK-dependent prodrugs. DCK, a rate-limiting enzyme in the deoxyribonucleoside salvage pathway for DNA synthesis, is overexpressed in certain solid tumors, lymphoid and myeloid malignancies and certain immune cells, such as proliferating T-lymphocytes. The L-enantiomer is less susceptible to deamination by cytidine deaminase (CDA) than the D-enantiomer and increases the stability of this radioconjugate." @default.
- NCIT_C105850 NCIT_A7 NCIT_C16498 @default.
- NCIT_C105850 NCIT_NHC0 "C105850" @default.
- NCIT_C105850 NCIT_P106 "Chemical" @default.
- NCIT_C105850 NCIT_P106 "Indicator, Reagent, or Diagnostic Aid" @default.
- NCIT_C105850 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C105850 NCIT_P107 "[18F]L-FMAC" @default.
- NCIT_C105850 NCIT_P108 "[18F]L-FMAC" @default.
- NCIT_C105850 NCIT_P208 "CL447178" @default.
- NCIT_C105850 NCIT_P210 "1134848-13-7" @default.
- NCIT_C105850 NCIT_P319 "1550OGY7TD" @default.
- NCIT_C105850 NCIT_P322 "CTRP" @default.
- NCIT_C105850 NCIT_P322 "FDA" @default.
- NCIT_C105850 NCIT_P329 "748182" @default.
- NCIT_C105850 NCIT_P330 "748182" @default.
- NCIT_C105850 NCIT_P399 "748182" @default.
- NCIT_C105850 normalizedInformationContent "100" @default.
- NCIT_C105850 referenceCount "1" @default.
- NCIT_C105850 hasExactSynonym "2'-Deoxy-2'-18F-fluoro-5-methyl-beta-L-arabinofuranosylcytosine" @default.
- NCIT_C105850 hasExactSynonym "L-FMAC F-18" @default.
- NCIT_C105850 hasExactSynonym "L-fluorine F 18-FMAC" @default.
- NCIT_C105850 hasExactSynonym "[18F]L-FMAC" @default.
- NCIT_C105850 inSubset NCIT_C116977 @default.
- NCIT_C105850 inSubset NCIT_C116978 @default.
- NCIT_C105850 inSubset NCIT_C176424 @default.
- NCIT_C105850 inSubset NCIT_C63923 @default.
- NCIT_C105850 type Class @default.
- NCIT_C105850 isDefinedBy ncit.owl @default.
- NCIT_C105850 label "[18F]L-FMAC" @default.
- NCIT_C105850 subClassOf NCIT_C105850 @default.
- NCIT_C105850 subClassOf NCIT_C1446 @default.
- NCIT_C105850 subClassOf NCIT_C1908 @default.
- NCIT_C105850 subClassOf NCIT_C1909 @default.
- NCIT_C105850 subClassOf NCIT_C2124 @default.