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- NCIT_C105851 IAO_0000115 "An orally bioavailable citrate salt form of zotiraciclib a multi-kinase inhibitor for cyclin dependent kinase (CDK) subtypes 1, 2, 7 and 9, Janus-associated kinase 2 (JAK2), FMS-related tyrosine kinase 3 (FLT3, FLK2, STK1), with potential antineoplastic activity. Upon oral administration, CDK/JAK2/FLT3 Inhibitor TG02 binds to and inhibits the CDK subtypes, JAK2, and FLT3. TG02 also inhibits, to a lesser extent, TYK2, TYRO3, STAT5 and P38delta. This may result in both an induction of apoptosis and an inhibition of tumor cell proliferation in cancer cells that overexpress these kinases. JAK2, often upregulated or mutated in a variety of cancer cells, mediates STAT3 activation and plays a key role in tumor cell proliferation and survival. CDKs are serine/threonine kinases that play key roles in the regulation of the cell cycle and cellular proliferation. FLT3, a class III tyrosine kinase receptor, is overexpressed or mutated in most B lineage and acute myeloid leukemias." @default.
- NCIT_C105851 NCIT_A32 NCIT_C1909 @default.
- NCIT_C105851 NCIT_A7 NCIT_C126982 @default.
- NCIT_C105851 NCIT_A7 NCIT_C17386 @default.
- NCIT_C105851 NCIT_A7 NCIT_C25842 @default.
- NCIT_C105851 NCIT_A7 NCIT_C26202 @default.
- NCIT_C105851 NCIT_A7 NCIT_C28494 @default.
- NCIT_C105851 NCIT_A7 NCIT_C89769 @default.
- NCIT_C105851 NCIT_NHC0 "C105851" @default.
- NCIT_C105851 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C105851 NCIT_P107 "Zotiraciclib Citrate" @default.
- NCIT_C105851 NCIT_P108 "Zotiraciclib Citrate" @default.
- NCIT_C105851 NCIT_P208 "CL447179" @default.
- NCIT_C105851 NCIT_P210 "1204918-73-9" @default.
- NCIT_C105851 NCIT_P319 "3VF50SU4RZ" @default.
- NCIT_C105851 NCIT_P322 "CTRP" @default.
- NCIT_C105851 NCIT_P322 "FDA" @default.
- NCIT_C105851 NCIT_P322 "GDC" @default.
- NCIT_C105851 NCIT_P329 "686272" @default.
- NCIT_C105851 NCIT_P330 "686272" @default.
- NCIT_C105851 NCIT_P375 "CDK/JAK2/FLT3 Inhibitor TG02 Citrate" @default.
- NCIT_C105851 NCIT_P375 "Zotiraciclib Citrate" @default.
- NCIT_C105851 NCIT_P399 "686272" @default.
- NCIT_C105851 normalizedInformationContent "100" @default.
- NCIT_C105851 referenceCount "1" @default.
- NCIT_C105851 hasExactSynonym "20-Oxa-5,7,14,27-tetraazatetracyclo(19.3.1.12,6.18,12)heptacosa-1(25),2,4,6(27),8,10,12(26),16,21,23-decaene, 14-Methyl-, 2-Hydroxy-1,2,3-propanetricarboxylate (1:1)" @default.
- NCIT_C105851 hasExactSynonym "SB1317 Citrate" @default.
- NCIT_C105851 hasExactSynonym "TG02 Citrate" @default.
- NCIT_C105851 hasExactSynonym "ZOTIRACICLIB CITRATE" @default.
- NCIT_C105851 hasExactSynonym "Zotiraciclib Citrate" @default.
- NCIT_C105851 inSubset NCIT_C116977 @default.
- NCIT_C105851 inSubset NCIT_C116978 @default.
- NCIT_C105851 inSubset NCIT_C128784 @default.
- NCIT_C105851 inSubset NCIT_C157711 @default.
- NCIT_C105851 inSubset NCIT_C157712 @default.
- NCIT_C105851 inSubset NCIT_C176424 @default.
- NCIT_C105851 inSubset NCIT_C177537 @default.
- NCIT_C105851 inSubset NCIT_C63923 @default.
- NCIT_C105851 type Class @default.
- NCIT_C105851 isDefinedBy ncit.owl @default.
- NCIT_C105851 label "Zotiraciclib Citrate" @default.
- NCIT_C105851 subClassOf NCIT_C105851 @default.
- NCIT_C105851 subClassOf NCIT_C129824 @default.
- NCIT_C105851 subClassOf NCIT_C129825 @default.
- NCIT_C105851 subClassOf NCIT_C1404 @default.
- NCIT_C105851 subClassOf NCIT_C1908 @default.
- NCIT_C105851 subClassOf NCIT_C1909 @default.
- NCIT_C105851 subClassOf NCIT_C2189 @default.
- NCIT_C105851 subClassOf NCIT_C274 @default.
- NCIT_C105851 subClassOf NCIT_C471 @default.