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- NCIT_C105853 IAO_0000115 "The dimesylate salt form of LY2228820, a tri-substituted imidazole derivative and orally available, p38 mitogen-activated protein kinase (MAPK) inhibitor with potential anti-inflammatory and antineoplastic activities. Upon administration, ralimetinib inhibits the activity of p38, particularly the alpha and beta isoforms, thereby inhibiting MAPKAPK2 phosphorylation and preventing p38 MAPK-mediated signaling. This may inhibit the production of a variety of cytokines involved in inflammation, cellular proliferation and angiogenesis such as tumor necrosis factor alpha (TNFa), interleukin (IL)-1, -6 and -8, vascular endothelial growth factor, and macrophage inflammatory protein-1 alpha. Ultimately this induces apoptosis and reduces tumor cell proliferation. In addition, inhibition of the p38 MAPK pathway by LY2228820 increases the antineoplastic activity of certain chemotherapeutic agents. p38 MAPK, a serine/threonine protein kinase that is often upregulated in cancer cells, plays a crucial role in tumor cell proliferation, angiogenesis and metastasis." @default.
- NCIT_C105853 NCIT_A32 NCIT_C1909 @default.
- NCIT_C105853 NCIT_A7 NCIT_C26364 @default.
- NCIT_C105853 NCIT_A7 NCIT_C26369 @default.
- NCIT_C105853 NCIT_NHC0 "C105853" @default.
- NCIT_C105853 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C105853 NCIT_P107 "Ralimetinib Mesylate" @default.
- NCIT_C105853 NCIT_P108 "Ralimetinib Mesylate" @default.
- NCIT_C105853 NCIT_P207 "C3659483" @default.
- NCIT_C105853 NCIT_P210 "862507-23-1" @default.
- NCIT_C105853 NCIT_P319 "QUW7B71FO9" @default.
- NCIT_C105853 NCIT_P322 "CTRP" @default.
- NCIT_C105853 NCIT_P322 "FDA" @default.
- NCIT_C105853 NCIT_P322 "GDC" @default.
- NCIT_C105853 NCIT_P329 "687387" @default.
- NCIT_C105853 NCIT_P330 "687387" @default.
- NCIT_C105853 NCIT_P375 "Ralimetinib Mesylate" @default.
- NCIT_C105853 NCIT_P399 "687387" @default.
- NCIT_C105853 normalizedInformationContent "100" @default.
- NCIT_C105853 referenceCount "1" @default.
- NCIT_C105853 hasExactSynonym "3H-Imidazo(4,5-b)pyridin-2-amine, 5-(2-(1,1-dimethylethyl)-4-(4-fluorophenyl)-1H-imidazol-5-yl)-3-(2,2-dimethylpropyl)-, Methanesulfonate (1:2)" @default.
- NCIT_C105853 hasExactSynonym "LY-2228820" @default.
- NCIT_C105853 hasExactSynonym "LY2228820 Dimesylate" @default.
- NCIT_C105853 hasExactSynonym "LY2228820" @default.
- NCIT_C105853 hasExactSynonym "RALIMETINIB MESYLATE" @default.
- NCIT_C105853 hasExactSynonym "Ralimetinib Dimesylate" @default.
- NCIT_C105853 hasExactSynonym "Ralimetinib Mesylate" @default.
- NCIT_C105853 inSubset NCIT_C116977 @default.
- NCIT_C105853 inSubset NCIT_C116978 @default.
- NCIT_C105853 inSubset NCIT_C128784 @default.
- NCIT_C105853 inSubset NCIT_C157711 @default.
- NCIT_C105853 inSubset NCIT_C157712 @default.
- NCIT_C105853 inSubset NCIT_C176424 @default.
- NCIT_C105853 inSubset NCIT_C177537 @default.
- NCIT_C105853 inSubset NCIT_C63923 @default.
- NCIT_C105853 type Class @default.
- NCIT_C105853 isDefinedBy ncit.owl @default.
- NCIT_C105853 label "Ralimetinib Mesylate" @default.
- NCIT_C105853 subClassOf NCIT_C105853 @default.
- NCIT_C105853 subClassOf NCIT_C129824 @default.
- NCIT_C105853 subClassOf NCIT_C129825 @default.
- NCIT_C105853 subClassOf NCIT_C1404 @default.
- NCIT_C105853 subClassOf NCIT_C1908 @default.
- NCIT_C105853 subClassOf NCIT_C1909 @default.
- NCIT_C105853 subClassOf NCIT_C2189 @default.
- NCIT_C105853 subClassOf NCIT_C274 @default.
- NCIT_C105853 subClassOf NCIT_C471 @default.
- NCIT_C105853 subClassOf NCIT_C61074 @default.