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- NCIT_C106118 IAO_0000115 "A humanized IgG1 insulin-like growth factor (IGF) monoclonal antibody targeting the IGF ligands 1 (IGF-1) and 2 (IGF-2), with potential antineoplastic activity. Upon administration, xentuzumab binds to both IGF-1 and IGF-2 and inhibits the binding of these ligands to their receptor, IGF-1R. This blocks the insulin growth factor (IGF) signaling pathway, which is upregulated in a number of cancer cell types and plays a key role in cancer cell proliferation and chemoresistance. In addition, BI 836845 prevents the binding of IGF-2 to insulin receptor variant A (IR-A), preventing its activation." @default.
- NCIT_C106118 NCIT_A32 NCIT_C1909 @default.
- NCIT_C106118 NCIT_A7 NCIT_C16743 @default.
- NCIT_C106118 NCIT_A7 NCIT_C16744 @default.
- NCIT_C106118 NCIT_NHC0 "C106118" @default.
- NCIT_C106118 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C106118 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C106118 NCIT_P107 "Xentuzumab" @default.
- NCIT_C106118 NCIT_P108 "Xentuzumab" @default.
- NCIT_C106118 NCIT_P207 "C3827152" @default.
- NCIT_C106118 NCIT_P210 "1417158-65-6" @default.
- NCIT_C106118 NCIT_P319 "X86Z1O656G" @default.
- NCIT_C106118 NCIT_P322 "CTRP" @default.
- NCIT_C106118 NCIT_P322 "FDA" @default.
- NCIT_C106118 NCIT_P322 "GDC" @default.
- NCIT_C106118 NCIT_P329 "697680" @default.
- NCIT_C106118 NCIT_P330 "697680" @default.
- NCIT_C106118 NCIT_P375 "Xentuzumab" @default.
- NCIT_C106118 NCIT_P399 "697680" @default.
- NCIT_C106118 NCIT_R124 NCIT_C17710 @default.
- NCIT_C106118 NCIT_R124 NCIT_C17828 @default.
- NCIT_C106118 NCIT_R124 NCIT_C18219 @default.
- NCIT_C106118 NCIT_R124 NCIT_C19986 @default.
- NCIT_C106118 NCIT_R124 NCIT_C40474 @default.
- NCIT_C106118 normalizedInformationContent "100" @default.
- NCIT_C106118 referenceCount "1" @default.
- NCIT_C106118 hasExactSynonym "BI 836845" @default.
- NCIT_C106118 hasExactSynonym "Immunoglobulin G1, Anti-(Human Insulin-like Growth Factor I) (Human Monoclonal PS05388 Heavy Chain), Disulfide with Human Monoclonal PS05388 Light Chain, Dimer" @default.
- NCIT_C106118 hasExactSynonym "XENTUZUMAB" @default.
- NCIT_C106118 hasExactSynonym "Xentuzumab" @default.
- NCIT_C106118 inSubset NCIT_C116977 @default.
- NCIT_C106118 inSubset NCIT_C116978 @default.
- NCIT_C106118 inSubset NCIT_C128784 @default.
- NCIT_C106118 inSubset NCIT_C157711 @default.
- NCIT_C106118 inSubset NCIT_C157712 @default.
- NCIT_C106118 inSubset NCIT_C176424 @default.
- NCIT_C106118 inSubset NCIT_C177537 @default.
- NCIT_C106118 inSubset NCIT_C63923 @default.
- NCIT_C106118 type Class @default.
- NCIT_C106118 isDefinedBy ncit.owl @default.
- NCIT_C106118 label "Xentuzumab" @default.
- NCIT_C106118 subClassOf NCIT_C106118 @default.
- NCIT_C106118 subClassOf NCIT_C129821 @default.
- NCIT_C106118 subClassOf NCIT_C129822 @default.
- NCIT_C106118 subClassOf NCIT_C1908 @default.
- NCIT_C106118 subClassOf NCIT_C1909 @default.
- NCIT_C106118 subClassOf NCIT_C20401 @default.
- NCIT_C106118 subClassOf NCIT_C274 @default.
- NCIT_C106118 subClassOf NCIT_C307 @default.
- NCIT_C106118 subClassOf NCIT_C308 @default.