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- NCIT_C106119 IAO_0000115 "An antibody drug conjugate (ADC) consisting of a humanized IgG1 monoclonal antibody targeting the MUC16 protein (CA-125) conjugated to, via a cleavable linker, the antimicrotubulin agent monomethyl auristatin E (MMAE), with potential antineoplastic activity. The monoclonal antibody moiety of sofituzumab vedotin selectively binds to MUC16. After internalization of the drug conjugate and proteolytic cleavage of the linker, MMAE binds to tubulin and inhibits its polymerization, which results in G2/M-phase growth arrest and tumor cell apoptosis. MUC16, a transmembrane protein, is overexpressed on the cell surface of more than 80 percent of ovarian cancer cells but not on healthy cells." @default.
- NCIT_C106119 NCIT_A32 NCIT_C1909 @default.
- NCIT_C106119 NCIT_A7 NCIT_C71020 @default.
- NCIT_C106119 NCIT_NHC0 "C106119" @default.
- NCIT_C106119 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C106119 NCIT_P107 "Sofituzumab Vedotin" @default.
- NCIT_C106119 NCIT_P108 "Sofituzumab Vedotin" @default.
- NCIT_C106119 NCIT_P208 "CL433830" @default.
- NCIT_C106119 NCIT_P210 "1418200-58-4" @default.
- NCIT_C106119 NCIT_P319 "2X3CKG601L" @default.
- NCIT_C106119 NCIT_P322 "CTRP" @default.
- NCIT_C106119 NCIT_P322 "FDA" @default.
- NCIT_C106119 NCIT_P322 "GDC" @default.
- NCIT_C106119 NCIT_P329 "699480" @default.
- NCIT_C106119 NCIT_P330 "699480" @default.
- NCIT_C106119 NCIT_P375 "Sofituzumab Vedotin" @default.
- NCIT_C106119 NCIT_P399 "699480" @default.
- NCIT_C106119 normalizedInformationContent "100" @default.
- NCIT_C106119 referenceCount "1" @default.
- NCIT_C106119 hasExactSynonym "DMUC5754A" @default.
- NCIT_C106119 hasExactSynonym "SOFITUZUMAB VEDOTIN" @default.
- NCIT_C106119 hasExactSynonym "Sofituzumab Vedotin" @default.
- NCIT_C106119 inSubset NCIT_C116977 @default.
- NCIT_C106119 inSubset NCIT_C116978 @default.
- NCIT_C106119 inSubset NCIT_C128784 @default.
- NCIT_C106119 inSubset NCIT_C157711 @default.
- NCIT_C106119 inSubset NCIT_C157712 @default.
- NCIT_C106119 inSubset NCIT_C176424 @default.
- NCIT_C106119 inSubset NCIT_C177537 @default.
- NCIT_C106119 inSubset NCIT_C63923 @default.
- NCIT_C106119 type Class @default.
- NCIT_C106119 isDefinedBy ncit.owl @default.
- NCIT_C106119 label "Sofituzumab Vedotin" @default.
- NCIT_C106119 subClassOf NCIT_C106119 @default.
- NCIT_C106119 subClassOf NCIT_C129821 @default.
- NCIT_C106119 subClassOf NCIT_C129823 @default.
- NCIT_C106119 subClassOf NCIT_C1512 @default.
- NCIT_C106119 subClassOf NCIT_C1908 @default.
- NCIT_C106119 subClassOf NCIT_C1909 @default.
- NCIT_C106119 subClassOf NCIT_C274 @default.
- NCIT_C106119 subClassOf NCIT_C307 @default.
- NCIT_C106119 subClassOf NCIT_C308 @default.