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- NCIT_C106126 IAO_0000115 "An orally available dual inhibitor of mitogen-activated protein kinase kinase (MEK) and Aurora kinases, with potential antineoplastic activity. Upon oral administration, MEK/Aurora kinase inhibitor BI 847325 selectively binds to and inhibits the activity of MEK, which both prevents the activation of MEK-dependent effector proteins and inhibits growth factor-mediated cell signaling. BI 847325 also binds to and inhibits the activity of the Aurora kinases A, B and C which may disrupt the assembly of the mitotic spindle apparatus, prevent chromosome segregation, and inhibit both cellular division and proliferation in Aurora kinase-overexpressing tumor cells. Altogether, this leads to the inhibition of cell proliferation and tumor growth as well as the induction of tumor regression. MEK, a dual-specificity threonine/tyrosine kinase that plays a key role in the activation of the RAS/RAF/MEK/ERK signaling pathway, is frequently upregulated in a variety of tumor cell types. Aurora kinases are serine-threonine kinases that play essential roles in mitotic checkpoint control and are overexpressed by a wide variety of cancer cell types." @default.
- NCIT_C106126 NCIT_A32 NCIT_C1909 @default.
- NCIT_C106126 NCIT_NHC0 "C106126" @default.
- NCIT_C106126 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C106126 NCIT_P108 "MEK/Aurora Kinase Inhibitor BI 847325" @default.
- NCIT_C106126 NCIT_P207 "C3827151" @default.
- NCIT_C106126 NCIT_P322 "GDC" @default.
- NCIT_C106126 NCIT_P329 "698315" @default.
- NCIT_C106126 NCIT_P330 "698315" @default.
- NCIT_C106126 NCIT_P375 "MEK/Aurora Kinase Inhibitor BI 847325" @default.
- NCIT_C106126 NCIT_P399 "698315" @default.
- NCIT_C106126 normalizedInformationContent "100" @default.
- NCIT_C106126 referenceCount "1" @default.
- NCIT_C106126 hasExactSynonym "BI 847325" @default.
- NCIT_C106126 hasExactSynonym "MEK/Aurora Kinase Inhibitor BI 847325" @default.
- NCIT_C106126 inSubset NCIT_C128784 @default.
- NCIT_C106126 inSubset NCIT_C157711 @default.
- NCIT_C106126 inSubset NCIT_C157712 @default.
- NCIT_C106126 inSubset NCIT_C176424 @default.
- NCIT_C106126 inSubset NCIT_C177537 @default.
- NCIT_C106126 type Class @default.
- NCIT_C106126 isDefinedBy ncit.owl @default.
- NCIT_C106126 label "MEK/Aurora Kinase Inhibitor BI 847325" @default.
- NCIT_C106126 subClassOf NCIT_C106126 @default.
- NCIT_C106126 subClassOf NCIT_C129824 @default.
- NCIT_C106126 subClassOf NCIT_C129825 @default.
- NCIT_C106126 subClassOf NCIT_C1404 @default.
- NCIT_C106126 subClassOf NCIT_C1908 @default.
- NCIT_C106126 subClassOf NCIT_C1909 @default.
- NCIT_C106126 subClassOf NCIT_C2189 @default.
- NCIT_C106126 subClassOf NCIT_C274 @default.
- NCIT_C106126 subClassOf NCIT_C471 @default.