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- NCIT_C106231 IAO_0000115 "A prostate cancer vaccine containing six messenger RNAs (mRNAs) encoding for antigens upregulated in prostate cancer, including mRNAs for prostate specific antigen (PSA), prostate specific membrane antigen (PSMA), prostatic acid phosphatase (PAP), and mucin 1 (MUC1), with potential antineoplastic and immunomodulating activities. Upon intradermal administration of mRNA-derived prostate cancer vaccine CV9104, this agent enters cells, the mRNAs are translated into the respective prostate specific antigens and may cause the immune system to mount a cytotoxic T lymphocyte response (CTL) against PSA-, PSMA-, PAP- and MUC1-expressing prostate tumor cells. The mRNAs used in this vaccine are modified to have enhanced translational potency and adjuvant activities. PSA, PSMA, PAP and MUC1 are frequently upregulated in prostate cancer cells; their expression in prostate cancer has been correlated with disease progression." @default.
- NCIT_C106231 NCIT_A32 NCIT_C1909 @default.
- NCIT_C106231 NCIT_NHC0 "C106231" @default.
- NCIT_C106231 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C106231 NCIT_P108 "mRNA-derived Prostate Cancer Vaccine CV9104" @default.
- NCIT_C106231 NCIT_P208 "CL447407" @default.
- NCIT_C106231 NCIT_P322 "GDC" @default.
- NCIT_C106231 NCIT_P329 "748869" @default.
- NCIT_C106231 NCIT_P330 "748869" @default.
- NCIT_C106231 NCIT_P375 "mRNA-derived Prostate Cancer Vaccine CV9104" @default.
- NCIT_C106231 NCIT_P399 "748869" @default.
- NCIT_C106231 normalizedInformationContent "100" @default.
- NCIT_C106231 referenceCount "1" @default.
- NCIT_C106231 hasExactSynonym "CV9104" @default.
- NCIT_C106231 hasExactSynonym "RNActive-derived Prostate Cancer Vaccine CV9104" @default.
- NCIT_C106231 hasExactSynonym "mRNA-derived Prostate Cancer Vaccine CV9104" @default.
- NCIT_C106231 inSubset NCIT_C128784 @default.
- NCIT_C106231 inSubset NCIT_C157711 @default.
- NCIT_C106231 inSubset NCIT_C157712 @default.
- NCIT_C106231 inSubset NCIT_C176424 @default.
- NCIT_C106231 inSubset NCIT_C177537 @default.
- NCIT_C106231 type Class @default.
- NCIT_C106231 isDefinedBy ncit.owl @default.
- NCIT_C106231 label "mRNA-derived Prostate Cancer Vaccine CV9104" @default.
- NCIT_C106231 subClassOf NCIT_C106231 @default.
- NCIT_C106231 subClassOf NCIT_C129820 @default.
- NCIT_C106231 subClassOf NCIT_C1663 @default.
- NCIT_C106231 subClassOf NCIT_C172787 @default.
- NCIT_C106231 subClassOf NCIT_C181141 @default.
- NCIT_C106231 subClassOf NCIT_C1908 @default.
- NCIT_C106231 subClassOf NCIT_C1909 @default.
- NCIT_C106231 subClassOf NCIT_C274 @default.
- NCIT_C106231 subClassOf NCIT_C307 @default.
- NCIT_C106231 subClassOf NCIT_C308 @default.
- NCIT_C106231 subClassOf NCIT_C923 @default.