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- NCIT_C106242 IAO_0000115 "A genetically-modified, dendritic cell-based (DCs) vaccine in which the autologous cells are transduced with an adenoviral vector expressing the tumor antigen prostate-specific membrane antigen (PSMA) and a fusion protein composed of synthetic ligand inducible adjuvant iMC composed of a drug-inducible costimulatory CD40 receptor (iCD40) and the adaptor protein MyD88, with potential immunomodulating and antineoplastic activities. The iCD40 contains a membrane-localized cytoplasmic CD40 domain fused to the FK506 modified drug-binding protein 12 (FKBP12). Upon intradermal administration of BPX-201, these DCs accumulate in local draining lymph nodes. Twenty-four hours after vaccination, the dimerizing agent AP1903 is administered. AP1903 binds to the drug binding domain, leading to iMC oligomerization and activation of iCD40 and MyD88-mediated signaling in iMC-expressing DCs. This signaling pathway activates the DCs and stimulates a cytotoxic T-lymphocyte (CTL) response against host tumor cells that express PSMA. PSMA, a glycoprotein secreted by prostatic epithelial and ductal cells, is overexpressed in prostate cancer cells and is used as a tumor marker for both diagnosis and treatment evaluation. MyD88 is involved in interleukin 1 receptor (IL1R) and toll-like receptor (TLR) signaling." @default.
- NCIT_C106242 NCIT_A32 NCIT_C1909 @default.
- NCIT_C106242 NCIT_A7 NCIT_C17796 @default.
- NCIT_C106242 NCIT_NHC0 "C106242" @default.
- NCIT_C106242 NCIT_P106 "Cell" @default.
- NCIT_C106242 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C106242 NCIT_P107 "Adenovector-transduced AP1903-inducible MyD88/CD40-expressing Autologous PSMA-specific Prostate Cancer Vaccine BPX-201" @default.
- NCIT_C106242 NCIT_P108 "Adenovector-transduced AP1903-inducible MyD88/CD40-expressing Autologous PSMA-specific Prostate Cancer Vaccine BPX-201" @default.
- NCIT_C106242 NCIT_P208 "CL447413" @default.
- NCIT_C106242 NCIT_P322 "CTRP" @default.
- NCIT_C106242 NCIT_P322 "GDC" @default.
- NCIT_C106242 NCIT_P329 "748904" @default.
- NCIT_C106242 NCIT_P330 "748904" @default.
- NCIT_C106242 NCIT_P375 "Adenovector-transduced AP1903-inducible MyD88/CD40-expressing Autologous PSMA-specific Prostate Cancer Vaccine BPX-201" @default.
- NCIT_C106242 NCIT_P399 "748904" @default.
- NCIT_C106242 normalizedInformationContent "100" @default.
- NCIT_C106242 referenceCount "1" @default.
- NCIT_C106242 hasExactSynonym "Adenovector-transduced AP1903-inducible MyD88/CD40-expressing Autologous PSMA-specific Prostate Cancer Vaccine BPX-201" @default.
- NCIT_C106242 hasExactSynonym "Adenovector-transduced AP1903-inducible iMC-expressing Autologous PSMA-specific Prostate Cancer Vaccine BPX-201" @default.
- NCIT_C106242 hasExactSynonym "BPX-201" @default.
- NCIT_C106242 inSubset NCIT_C116977 @default.
- NCIT_C106242 inSubset NCIT_C116978 @default.
- NCIT_C106242 inSubset NCIT_C128784 @default.
- NCIT_C106242 inSubset NCIT_C157711 @default.
- NCIT_C106242 inSubset NCIT_C157712 @default.
- NCIT_C106242 inSubset NCIT_C176424 @default.
- NCIT_C106242 inSubset NCIT_C177537 @default.
- NCIT_C106242 type Class @default.
- NCIT_C106242 isDefinedBy ncit.owl @default.
- NCIT_C106242 label "Adenovector-transduced AP1903-inducible MyD88/CD40-expressing Autologous PSMA-specific Prostate Cancer Vaccine BPX-201" @default.
- NCIT_C106242 subClassOf NCIT_C106242 @default.
- NCIT_C106242 subClassOf NCIT_C129820 @default.
- NCIT_C106242 subClassOf NCIT_C142078 @default.
- NCIT_C106242 subClassOf NCIT_C154231 @default.
- NCIT_C106242 subClassOf NCIT_C1663 @default.
- NCIT_C106242 subClassOf NCIT_C1908 @default.
- NCIT_C106242 subClassOf NCIT_C1909 @default.
- NCIT_C106242 subClassOf NCIT_C1962 @default.
- NCIT_C106242 subClassOf NCIT_C274 @default.
- NCIT_C106242 subClassOf NCIT_C28308 @default.
- NCIT_C106242 subClassOf NCIT_C28310 @default.
- NCIT_C106242 subClassOf NCIT_C307 @default.
- NCIT_C106242 subClassOf NCIT_C308 @default.
- NCIT_C106242 subClassOf NCIT_C923 @default.