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- NCIT_C106253 IAO_0000115 "An inhibitor of CXC chemokine receptor 4 (CXCR4), with potential antineoplastic activity. Upon subcutaneous administration, CXCR4 inhibitor LY2510924 binds to the chemokine receptor CXCR4, thereby preventing CXCR4 binding to its ligand, stromal derived factor-1 (SDF-1), and subsequent receptor activation. This may result in decreased tumor cell proliferation and migration. CXCR4, a chemokine receptor belonging to the G protein-coupled receptor (GPCR) gene family, plays an important role in chemotaxis and angiogenesis and is upregulated in several tumor cell types." @default.
- NCIT_C106253 NCIT_A32 NCIT_C1909 @default.
- NCIT_C106253 NCIT_A7 NCIT_C17789 @default.
- NCIT_C106253 NCIT_NHC0 "C106253" @default.
- NCIT_C106253 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C106253 NCIT_P107 "CXCR4 Peptide Antagonist LY2510924" @default.
- NCIT_C106253 NCIT_P108 "CXCR4 Peptide Antagonist LY2510924" @default.
- NCIT_C106253 NCIT_P207 "C3827103" @default.
- NCIT_C106253 NCIT_P322 "CTRP" @default.
- NCIT_C106253 NCIT_P322 "GDC" @default.
- NCIT_C106253 NCIT_P329 "703819" @default.
- NCIT_C106253 NCIT_P330 "703819" @default.
- NCIT_C106253 NCIT_P375 "CXCR4 Peptide Antagonist LY2510924" @default.
- NCIT_C106253 NCIT_P399 "703819" @default.
- NCIT_C106253 normalizedInformationContent "100" @default.
- NCIT_C106253 referenceCount "1" @default.
- NCIT_C106253 hasExactSynonym "CXCR4 Peptide Antagonist LY2510924" @default.
- NCIT_C106253 hasExactSynonym "LY2510924" @default.
- NCIT_C106253 inSubset NCIT_C116977 @default.
- NCIT_C106253 inSubset NCIT_C116978 @default.
- NCIT_C106253 inSubset NCIT_C128784 @default.
- NCIT_C106253 inSubset NCIT_C157711 @default.
- NCIT_C106253 inSubset NCIT_C157712 @default.
- NCIT_C106253 inSubset NCIT_C176424 @default.
- NCIT_C106253 inSubset NCIT_C177537 @default.
- NCIT_C106253 type Class @default.
- NCIT_C106253 isDefinedBy ncit.owl @default.
- NCIT_C106253 label "CXCR4 Peptide Antagonist LY2510924" @default.
- NCIT_C106253 subClassOf NCIT_C106253 @default.
- NCIT_C106253 subClassOf NCIT_C129824 @default.
- NCIT_C106253 subClassOf NCIT_C1908 @default.
- NCIT_C106253 subClassOf NCIT_C1909 @default.
- NCIT_C106253 subClassOf NCIT_C2189 @default.
- NCIT_C106253 subClassOf NCIT_C274 @default.