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- NCIT_C106261 IAO_0000115 "An orally bioavailable, substituted benzimidazole inhibitor of the class I phosphoinositide 3-kinase (PI3K) beta isoform with potential antineoplastic activity. PI3K beta inhibitor GSK2636771 selectively inhibits PI3K beta kinase activity in the PI3K/Akt/mTOR pathway, which may result in tumor cell apoptosis and growth inhibition in PI3K beta-expressing and/or PTEN-driven tumor cells. Dysregulation of the PI3K/Akt/mTOR pathway is frequently found in solid tumors and results in the promotion of tumor cell growth, survival, and resistance to both chemotherapy and radiotherapy. PI3K beta is the p110-beta catalytic subunit of the class I PI3K. PTEN, a tumor suppressor protein and negative regulator of PI3K activity, is often mutated in a variety of cancer cells." @default.
- NCIT_C106261 NCIT_A32 NCIT_C1909 @default.
- NCIT_C106261 NCIT_A7 NCIT_C30170 @default.
- NCIT_C106261 NCIT_NHC0 "C106261" @default.
- NCIT_C106261 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C106261 NCIT_P107 "PI3K-beta Inhibitor GSK2636771" @default.
- NCIT_C106261 NCIT_P108 "PI3K-beta Inhibitor GSK2636771" @default.
- NCIT_C106261 NCIT_P208 "CL433894" @default.
- NCIT_C106261 NCIT_P210 "1372540-25-4" @default.
- NCIT_C106261 NCIT_P319 "DW94IAT0LS" @default.
- NCIT_C106261 NCIT_P322 "CTRP" @default.
- NCIT_C106261 NCIT_P322 "FDA" @default.
- NCIT_C106261 NCIT_P322 "GDC" @default.
- NCIT_C106261 NCIT_P329 "715683" @default.
- NCIT_C106261 NCIT_P330 "715683" @default.
- NCIT_C106261 NCIT_P375 "PI3K-beta Inhibitor GSK2636771" @default.
- NCIT_C106261 NCIT_P399 "715683" @default.
- NCIT_C106261 normalizedInformationContent "100" @default.
- NCIT_C106261 referenceCount "1" @default.
- NCIT_C106261 hasExactSynonym "GSK-2636771" @default.
- NCIT_C106261 hasExactSynonym "GSK2636771" @default.
- NCIT_C106261 hasExactSynonym "PI3K-beta Inhibitor GSK2636771" @default.
- NCIT_C106261 inSubset NCIT_C116977 @default.
- NCIT_C106261 inSubset NCIT_C116978 @default.
- NCIT_C106261 inSubset NCIT_C128784 @default.
- NCIT_C106261 inSubset NCIT_C157711 @default.
- NCIT_C106261 inSubset NCIT_C157712 @default.
- NCIT_C106261 inSubset NCIT_C176424 @default.
- NCIT_C106261 inSubset NCIT_C177537 @default.
- NCIT_C106261 inSubset NCIT_C63923 @default.
- NCIT_C106261 type Class @default.
- NCIT_C106261 isDefinedBy ncit.owl @default.
- NCIT_C106261 label "PI3K-beta Inhibitor GSK2636771" @default.
- NCIT_C106261 subClassOf NCIT_C106261 @default.
- NCIT_C106261 subClassOf NCIT_C129824 @default.
- NCIT_C106261 subClassOf NCIT_C129825 @default.
- NCIT_C106261 subClassOf NCIT_C1404 @default.
- NCIT_C106261 subClassOf NCIT_C163758 @default.
- NCIT_C106261 subClassOf NCIT_C1742 @default.
- NCIT_C106261 subClassOf NCIT_C1908 @default.
- NCIT_C106261 subClassOf NCIT_C1909 @default.
- NCIT_C106261 subClassOf NCIT_C2152 @default.
- NCIT_C106261 subClassOf NCIT_C2189 @default.
- NCIT_C106261 subClassOf NCIT_C274 @default.
- NCIT_C106261 subClassOf NCIT_C471 @default.