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- NCIT_C106271 IAO_0000115 "A systemic gene therapy anti-cancer agent composed of cationic liposomes, which encapsulates plasmid DNA encoding for the tumor suppressor gene RB94 and is complexed with anti-transferrin receptor single chain antibody fragment (TfRscFv), with potential antineoplastic activity. Upon systemic administration of liposome-encapsulated RB94 plasmid DNA gene therapy agent SGT-94, the TfRscFv portion of this agent selectively targets the tumor cells expressing transferrin receptors. TfRscFv binding to the transferrin receptor allows receptor-mediated endocytosis and transfection, followed by the expression of RB94 gene. This induces tumor cell apoptosis through an as of yet unknown pathway. RB94 is a modified, N-terminal truncated form of the full-length protein retinoblastoma gene RB110, and exerts enhanced antitumor activity. The transferrin receptor (TfR) functions in cellular iron uptake through its interaction with transferrin, and is overexpressed in a variety of tumor types." @default.
- NCIT_C106271 NCIT_A32 NCIT_C1909 @default.
- NCIT_C106271 NCIT_A7 NCIT_C38519 @default.
- NCIT_C106271 NCIT_NHC0 "C106271" @default.
- NCIT_C106271 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C106271 NCIT_P107 "Liposome-encapsulated RB94 Plasmid DNA Gene Therapy Agent SGT-94" @default.
- NCIT_C106271 NCIT_P108 "Liposome-encapsulated RB94 Plasmid DNA Gene Therapy Agent SGT-94" @default.
- NCIT_C106271 NCIT_P208 "CL433963" @default.
- NCIT_C106271 NCIT_P322 "CTRP" @default.
- NCIT_C106271 NCIT_P322 "GDC" @default.
- NCIT_C106271 NCIT_P329 "724243" @default.
- NCIT_C106271 NCIT_P330 "724243" @default.
- NCIT_C106271 NCIT_P375 "Liposome-encapsulated RB94 Plasmid DNA Gene Therapy Agent SGT-94" @default.
- NCIT_C106271 NCIT_P399 "724243" @default.
- NCIT_C106271 normalizedInformationContent "100" @default.
- NCIT_C106271 referenceCount "1" @default.
- NCIT_C106271 hasExactSynonym "Liposome-encapsulated RB94 Plasmid DNA Gene Therapy Agent SGT-94" @default.
- NCIT_C106271 hasExactSynonym "SGT-94" @default.
- NCIT_C106271 hasExactSynonym "TfRscFv/Lip/RB94" @default.
- NCIT_C106271 inSubset NCIT_C116977 @default.
- NCIT_C106271 inSubset NCIT_C116978 @default.
- NCIT_C106271 inSubset NCIT_C128784 @default.
- NCIT_C106271 inSubset NCIT_C157711 @default.
- NCIT_C106271 inSubset NCIT_C157712 @default.
- NCIT_C106271 inSubset NCIT_C176424 @default.
- NCIT_C106271 inSubset NCIT_C177537 @default.
- NCIT_C106271 type Class @default.
- NCIT_C106271 isDefinedBy ncit.owl @default.
- NCIT_C106271 label "Liposome-encapsulated RB94 Plasmid DNA Gene Therapy Agent SGT-94" @default.
- NCIT_C106271 subClassOf NCIT_C106271 @default.
- NCIT_C106271 subClassOf NCIT_C129821 @default.
- NCIT_C106271 subClassOf NCIT_C1908 @default.
- NCIT_C106271 subClassOf NCIT_C1909 @default.
- NCIT_C106271 subClassOf NCIT_C1962 @default.
- NCIT_C106271 subClassOf NCIT_C274 @default.
- NCIT_C106271 subClassOf NCIT_C307 @default.
- NCIT_C106271 subClassOf NCIT_C61199 @default.