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- NCIT_C106368 IAO_0000115 "The hydrochloride salt form of mocravimod, a sphingosine 1-phosphate (S1P) receptor agonist, with potential immunosuppressive activity. Upon administration of mocravimod, this agent binds to S1P receptors on lymphocytes, which prevents binding of serum S1P to S1P receptors and leads to S1P receptor internalization. This reduces the number of circulating blood leukocytes and accelerates lymphocyte homing into peripheral lymph nodes, thereby preventing their infiltration into peripheral inflammatory sites. This agent also decreases the production of inflammatory cytokines by lymphocytes, such as interferon gamma (IFN-g), interleukin-12 (IL-12), and tumor necrosis factor (TNF)." @default.
- NCIT_C106368 NCIT_A32 NCIT_C1909 @default.
- NCIT_C106368 NCIT_NHC0 "C106368" @default.
- NCIT_C106368 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C106368 NCIT_P108 "Mocravimod Hydrochloride" @default.
- NCIT_C106368 NCIT_P207 "C1570777" @default.
- NCIT_C106368 NCIT_P210 "509088-69-1" @default.
- NCIT_C106368 NCIT_P319 "3YH0N35CE3" @default.
- NCIT_C106368 NCIT_P322 "FDA" @default.
- NCIT_C106368 NCIT_P322 "GDC" @default.
- NCIT_C106368 NCIT_P329 "749378" @default.
- NCIT_C106368 NCIT_P330 "749378" @default.
- NCIT_C106368 NCIT_P375 "S1P Receptor Agonist KRP203" @default.
- NCIT_C106368 NCIT_P399 "749378" @default.
- NCIT_C106368 normalizedInformationContent "100" @default.
- NCIT_C106368 referenceCount "1" @default.
- NCIT_C106368 hasExactSynonym "2-Amino-2-propanediol Hydrochloride" @default.
- NCIT_C106368 hasExactSynonym "KRP-203" @default.
- NCIT_C106368 hasExactSynonym "KRP203" @default.
- NCIT_C106368 hasExactSynonym "MOCRAVIMOD HYDROCHLORIDE" @default.
- NCIT_C106368 hasExactSynonym "Mocravimod Hydrochloride" @default.
- NCIT_C106368 inSubset NCIT_C128784 @default.
- NCIT_C106368 inSubset NCIT_C157711 @default.
- NCIT_C106368 inSubset NCIT_C157712 @default.
- NCIT_C106368 inSubset NCIT_C176424 @default.
- NCIT_C106368 inSubset NCIT_C177537 @default.
- NCIT_C106368 inSubset NCIT_C63923 @default.
- NCIT_C106368 type Class @default.
- NCIT_C106368 isDefinedBy ncit.owl @default.
- NCIT_C106368 label "Mocravimod Hydrochloride" @default.
- NCIT_C106368 subClassOf NCIT_C106368 @default.
- NCIT_C106368 subClassOf NCIT_C1908 @default.
- NCIT_C106368 subClassOf NCIT_C1909 @default.
- NCIT_C106368 subClassOf NCIT_C308 @default.
- NCIT_C106368 subClassOf NCIT_C574 @default.