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- NCIT_C106369 IAO_0000115 "The hydrochloride salt form of simmitecan, an ester prodrug of chimmitecan, a 9-alkyl substituted camptothecin derivative with potential antineoplastc activity. Upon intravenous administration, simmitecan is hydrolyzed by carboxylesterase and the activated form, chimmitecan, is produced. Chimmitecan inhibits topoisomerase I, stabilizes covalent topoisomerase I-DNA complexes, and inhibits the religation of topoisomerase I-mediated single-strand DNA breaks. Futhermore, the covalent topoisomerase I-DNA complexes interfere and block the DNA replication machinery, resulting in the production of potentially lethal double-strand DNA breaks. This leads to an inhibition of DNA replication and the induction of apoptosis. The modification at position 9 yields improved cytotoxicity compared to some other camptothecin analogues." @default.
- NCIT_C106369 NCIT_NHC0 "C106369" @default.
- NCIT_C106369 NCIT_P106 "Organic Chemical" @default.
- NCIT_C106369 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C106369 NCIT_P108 "Simmitecan Hydrochloride" @default.
- NCIT_C106369 NCIT_P208 "CL447735" @default.
- NCIT_C106369 NCIT_P210 "1247847-78-4" @default.
- NCIT_C106369 NCIT_P319 "T4H02O147G" @default.
- NCIT_C106369 NCIT_P322 "FDA" @default.
- NCIT_C106369 NCIT_P329 "749475" @default.
- NCIT_C106369 NCIT_P330 "749475" @default.
- NCIT_C106369 NCIT_P399 "749475" @default.
- NCIT_C106369 normalizedInformationContent "100" @default.
- NCIT_C106369 referenceCount "1" @default.
- NCIT_C106369 hasExactSynonym "SIMMITECAN" @default.
- NCIT_C106369 hasExactSynonym "Simmitecan Hydrochloride" @default.
- NCIT_C106369 inSubset NCIT_C176424 @default.
- NCIT_C106369 inSubset NCIT_C63923 @default.
- NCIT_C106369 type Class @default.
- NCIT_C106369 isDefinedBy ncit.owl @default.
- NCIT_C106369 label "Simmitecan Hydrochloride" @default.
- NCIT_C106369 subClassOf NCIT_C106369 @default.
- NCIT_C106369 subClassOf NCIT_C129824 @default.
- NCIT_C106369 subClassOf NCIT_C129825 @default.
- NCIT_C106369 subClassOf NCIT_C1748 @default.
- NCIT_C106369 subClassOf NCIT_C1904 @default.
- NCIT_C106369 subClassOf NCIT_C1908 @default.
- NCIT_C106369 subClassOf NCIT_C1909 @default.
- NCIT_C106369 subClassOf NCIT_C2189 @default.
- NCIT_C106369 subClassOf NCIT_C274 @default.
- NCIT_C106369 subClassOf NCIT_C2843 @default.
- NCIT_C106369 subClassOf NCIT_C471 @default.