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- NCIT_C106370 IAO_0000115 "An orally bioavailable inhibitor of the proto-oncogene c-Met (also known as hepatocyte growth factor receptor (HGFR)) with potential antineoplastic activity. c-Met inhibitor MSC2156119J selectively binds to c-Met, which inhibits c-Met phosphorylation and disrupts c-Met-mediated signal transduction pathways. This may induce cell death in tumor cells overexpressing c-Met protein or expressing constitutively activated c-Met protein. c-Met, a receptor tyrosine kinase overexpressed or mutated in many tumor cell types, plays key roles in tumor cell proliferation, survival, invasion, metastasis, and tumor angiogenesis." @default.
- NCIT_C106370 NCIT_NHC0 "C106370" @default.
- NCIT_C106370 NCIT_P106 "Organic Chemical" @default.
- NCIT_C106370 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C106370 NCIT_P108 "c-Met Inhibitor MSC2156119J" @default.
- NCIT_C106370 NCIT_P200 "C129825" @default.
- NCIT_C106370 NCIT_P200 "C143099" @default.
- NCIT_C106370 NCIT_P310 "Retired_Concept" @default.
- NCIT_C106370 NCIT_P98 "Mon Jan 10 13:58:30 EST 2022 - See 'Tepotinib(C88314)'" @default.
- NCIT_C106370 normalizedInformationContent "100" @default.
- NCIT_C106370 referenceCount "1" @default.
- NCIT_C106370 hasExactSynonym "c-Met Inhibitor MSC2156119J" @default.
- NCIT_C106370 type Class @default.
- NCIT_C106370 isDefinedBy ncit.owl @default.
- NCIT_C106370 label "c-Met Inhibitor MSC2156119J" @default.
- NCIT_C106370 subClassOf NCIT_C106370 @default.
- NCIT_C106370 subClassOf NCIT_C192094 @default.
- NCIT_C106370 subClassOf NCIT_C28428 @default.
- NCIT_C106370 deprecated "true" @default.