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- NCIT_C106429 IAO_0000115 "Peripheral blood T-lymphocytes (PBTLs) transduced with a retroviral vector expressing a chimeric antigen receptor (CAR) consisting of an anti-CD19 scFv (single chain variable fragment) coupled to the costimulatory signaling domain CD28, the signaling domain of 4-1BB (CD137), and the zeta chain of the T-cell receptor (TCR), with potential immunomodulating and antineoplastic activities. Upon transfusion, PBTL CD19CAR-28/CD137zeta directs the T-lymphocytes to CD19-expressing tumor cells and induces selective toxicity in CD19-expressing tumor cells. CD28, a T-cell surface-associated co-stimulatory molecule, is required for full T-cell activation, proliferation, and survival. The 4-1BB co-stimulatory molecule signaling domain enhances activation and signaling after recognition of CD19. Furthermore, inclusion of the 4-1BB signaling domain may increase the antitumor activity compared to the inclusion of the CD28 costimulatory domain and TCR zeta chain alone. CD19 antigen is a B-cell specific cell surface antigen, which is expressed in all B-cell lineage malignancies." @default.
- NCIT_C106429 NCIT_A7 NCIT_C38894 @default.
- NCIT_C106429 NCIT_NHC0 "C106429" @default.
- NCIT_C106429 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C106429 NCIT_P107 "PBTL CD19CAR-28/CD137/zeta" @default.
- NCIT_C106429 NCIT_P108 "PBTL CD19CAR-28/CD137/zeta" @default.
- NCIT_C106429 NCIT_P207 "C3831433" @default.
- NCIT_C106429 NCIT_P322 "CTRP" @default.
- NCIT_C106429 NCIT_P329 "749810" @default.
- NCIT_C106429 NCIT_P330 "749810" @default.
- NCIT_C106429 NCIT_P399 "749810" @default.
- NCIT_C106429 normalizedInformationContent "100" @default.
- NCIT_C106429 referenceCount "1" @default.
- NCIT_C106429 hasExactSynonym "CD19CAR/28137-bearing ATLs" @default.
- NCIT_C106429 hasExactSynonym "PBTL CD19CAR-28/CD137/zeta" @default.
- NCIT_C106429 inSubset NCIT_C116977 @default.
- NCIT_C106429 inSubset NCIT_C116978 @default.
- NCIT_C106429 inSubset NCIT_C128784 @default.
- NCIT_C106429 inSubset NCIT_C176424 @default.
- NCIT_C106429 type Class @default.
- NCIT_C106429 isDefinedBy ncit.owl @default.
- NCIT_C106429 label "PBTL CD19CAR-28/CD137/zeta" @default.
- NCIT_C106429 subClassOf NCIT_C106429 @default.
- NCIT_C106429 subClassOf NCIT_C129820 @default.
- NCIT_C106429 subClassOf NCIT_C129821 @default.
- NCIT_C106429 subClassOf NCIT_C129826 @default.
- NCIT_C106429 subClassOf NCIT_C137999 @default.
- NCIT_C106429 subClassOf NCIT_C142078 @default.
- NCIT_C106429 subClassOf NCIT_C154231 @default.
- NCIT_C106429 subClassOf NCIT_C176018 @default.
- NCIT_C106429 subClassOf NCIT_C1908 @default.
- NCIT_C106429 subClassOf NCIT_C1909 @default.
- NCIT_C106429 subClassOf NCIT_C1962 @default.
- NCIT_C106429 subClassOf NCIT_C274 @default.
- NCIT_C106429 subClassOf NCIT_C307 @default.
- NCIT_C106429 subClassOf NCIT_C308 @default.