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- NCIT_C106430 IAO_0000115 "A water soluble inhibitor of the protein phosphatase 2A (PP2A), with potential chemo- and radiotherapy enhancing activity. Upon injection, PP2A inhibitor LB-100 inhibits the removal of phosphate groups from proteins essential for cell cycle progression. When used with radio- or chemotherapy treatment, this agent prevents the activation of PP2A-mediated repair mechanisms and allows for malignant cells to progress through the cell cycle without having their damaged DNA repaired. This enhances the cytotoxic effect of the chemotherapeutic or radiotherapeutic agent and results in tumor cell apoptosis. PP2A, a serine/threonine phosphatase that plays a key role in the control of cell growth and DNA damage repair." @default.
- NCIT_C106430 NCIT_A32 NCIT_C1909 @default.
- NCIT_C106430 NCIT_NHC0 "C106430" @default.
- NCIT_C106430 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C106430 NCIT_P108 "Protein Phosphatase 2A Inhibitor LB-100" @default.
- NCIT_C106430 NCIT_P207 "C3827105" @default.
- NCIT_C106430 NCIT_P210 "1632032-53-1" @default.
- NCIT_C106430 NCIT_P319 "0C1JUU9S0L" @default.
- NCIT_C106430 NCIT_P322 "FDA" @default.
- NCIT_C106430 NCIT_P322 "GDC" @default.
- NCIT_C106430 NCIT_P329 "749984" @default.
- NCIT_C106430 NCIT_P330 "749984" @default.
- NCIT_C106430 NCIT_P375 "Protein Phosphatase 2A Inhibitor LB-100" @default.
- NCIT_C106430 NCIT_P399 "749984" @default.
- NCIT_C106430 normalizedInformationContent "100" @default.
- NCIT_C106430 referenceCount "1" @default.
- NCIT_C106430 hasExactSynonym "LB-100" @default.
- NCIT_C106430 hasExactSynonym "PP2A Inhibitor LB-100" @default.
- NCIT_C106430 hasExactSynonym "Protein Phosphatase 2A Inhibitor LB-100" @default.
- NCIT_C106430 inSubset NCIT_C128784 @default.
- NCIT_C106430 inSubset NCIT_C157711 @default.
- NCIT_C106430 inSubset NCIT_C157712 @default.
- NCIT_C106430 inSubset NCIT_C176424 @default.
- NCIT_C106430 inSubset NCIT_C177537 @default.
- NCIT_C106430 inSubset NCIT_C63923 @default.
- NCIT_C106430 type Class @default.
- NCIT_C106430 isDefinedBy ncit.owl @default.
- NCIT_C106430 label "Protein Phosphatase 2A Inhibitor LB-100" @default.
- NCIT_C106430 subClassOf NCIT_C106430 @default.
- NCIT_C106430 subClassOf NCIT_C1908 @default.
- NCIT_C106430 subClassOf NCIT_C1909 @default.
- NCIT_C106430 subClassOf NCIT_C2159 @default.
- NCIT_C106430 subClassOf NCIT_C471 @default.