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- NCIT_C107164 IAO_0000115 "A dimethane sulfonate derivative and alkylating agent with a structure similar to other alkylating agents such as chlorambucil, busulfan and melphalan, with potential antineoplastic activity. Although the exact mechanism of action has yet to be fully elucidated, benzaldehyde dimethane sulfonate alkylates DNA, which results in DNA double strand breaks, inhibition of DNA replication, cell cycle arrest and cell death. In addition, this agent is metabolized by the enzyme aldehyde dehydrogenase (ALDH) into the active carboxylic acid metabolite benzoic acid dimethane sulfonate (BA), which further contributes to its alkylating activity. Unlike other alkylating agents, benzaldehyde dimethane sulfonate has demonstrated antitumor activity in renal cell carcinoma." @default.
- NCIT_C107164 NCIT_A32 NCIT_C1909 @default.
- NCIT_C107164 NCIT_NHC0 "C107164" @default.
- NCIT_C107164 NCIT_P106 "Organic Chemical" @default.
- NCIT_C107164 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C107164 NCIT_P107 "Benzaldehyde Dimethane Sulfonate" @default.
- NCIT_C107164 NCIT_P108 "Benzaldehyde Dimethane Sulfonate" @default.
- NCIT_C107164 NCIT_P207 "C3661349" @default.
- NCIT_C107164 NCIT_P210 "56967-08-9" @default.
- NCIT_C107164 NCIT_P319 "96B0BRI1JU" @default.
- NCIT_C107164 NCIT_P322 "CTRP" @default.
- NCIT_C107164 NCIT_P322 "FDA" @default.
- NCIT_C107164 NCIT_P322 "GDC" @default.
- NCIT_C107164 NCIT_P329 "750365" @default.
- NCIT_C107164 NCIT_P330 "750365" @default.
- NCIT_C107164 NCIT_P375 "Benzaldehyde Dimethane Sulfonate" @default.
- NCIT_C107164 NCIT_P399 "750365" @default.
- NCIT_C107164 normalizedInformationContent "100" @default.
- NCIT_C107164 referenceCount "1" @default.
- NCIT_C107164 hasExactSynonym "BEN" @default.
- NCIT_C107164 hasExactSynonym "Benzaldehyde Dimethane Sulfonate" @default.
- NCIT_C107164 hasExactSynonym "DMS-612" @default.
- NCIT_C107164 hasExactSynonym "DMS612" @default.
- NCIT_C107164 hasExactSynonym "NSC 281612" @default.
- NCIT_C107164 inSubset NCIT_C116977 @default.
- NCIT_C107164 inSubset NCIT_C116978 @default.
- NCIT_C107164 inSubset NCIT_C128784 @default.
- NCIT_C107164 inSubset NCIT_C157711 @default.
- NCIT_C107164 inSubset NCIT_C157712 @default.
- NCIT_C107164 inSubset NCIT_C176424 @default.
- NCIT_C107164 inSubset NCIT_C177537 @default.
- NCIT_C107164 inSubset NCIT_C63923 @default.
- NCIT_C107164 type Class @default.
- NCIT_C107164 isDefinedBy ncit.owl @default.
- NCIT_C107164 label "Benzaldehyde Dimethane Sulfonate" @default.
- NCIT_C107164 subClassOf NCIT_C107164 @default.
- NCIT_C107164 subClassOf NCIT_C1590 @default.
- NCIT_C107164 subClassOf NCIT_C186664 @default.
- NCIT_C107164 subClassOf NCIT_C1908 @default.
- NCIT_C107164 subClassOf NCIT_C1909 @default.
- NCIT_C107164 subClassOf NCIT_C274 @default.
- NCIT_C107164 subClassOf NCIT_C2842 @default.