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- NCIT_C107188 IAO_0000115 "An orally available, mucoadhesive lipid preparation consisting of paclitaxel, a compound extracted from the Pacific yew tree Taxus brevifolia, in a formulation that is comprised of a mixture of monoolein, tricarprylin, and Tween 80, with potential antineoplastic activity. Upon oral administration, DHP107 forms droplets and micelles in the intestine; these adhere to mucoepithelial cells in the gastrointestinal tract and are absorbed through lipid-based uptake mechanisms. Upon absorption, paclitaxel binds to and stabilizes tubulin molecules, which results in the inhibition of both microtubule depolymerization and cell division. This agent also induces apoptosis by both binding to and blocking the function of the apoptosis inhibitor protein B-cell Leukemia 2 (Bcl-2).The mucoadhesive paclitaxel formulation does not contain P-glycoprotein inhibitors, the solvent cremophor or any other toxic solvent." @default.
- NCIT_C107188 NCIT_A32 NCIT_C1909 @default.
- NCIT_C107188 NCIT_NHC0 "C107188" @default.
- NCIT_C107188 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C107188 NCIT_P107 "Mucoadhesive Paclitaxel Formulation" @default.
- NCIT_C107188 NCIT_P108 "Mucoadhesive Paclitaxel Formulation" @default.
- NCIT_C107188 NCIT_P208 "CL449448" @default.
- NCIT_C107188 NCIT_P322 "CTRP" @default.
- NCIT_C107188 NCIT_P322 "GDC" @default.
- NCIT_C107188 NCIT_P329 "750455" @default.
- NCIT_C107188 NCIT_P330 "750455" @default.
- NCIT_C107188 NCIT_P375 "Mucoadhesive Paclitaxel Formulation" @default.
- NCIT_C107188 NCIT_P399 "750455" @default.
- NCIT_C107188 NCIT_R124 NCIT_C17828 @default.
- NCIT_C107188 NCIT_R124 NCIT_C20480 @default.
- NCIT_C107188 NCIT_R124 NCIT_C40795 @default.
- NCIT_C107188 NCIT_R124 NCIT_C40798 @default.
- NCIT_C107188 normalizedInformationContent "100" @default.
- NCIT_C107188 referenceCount "1" @default.
- NCIT_C107188 hasExactSynonym "DHP107" @default.
- NCIT_C107188 hasExactSynonym "Mucoadhesive Paclitaxel Formulation" @default.
- NCIT_C107188 inSubset NCIT_C116977 @default.
- NCIT_C107188 inSubset NCIT_C116978 @default.
- NCIT_C107188 inSubset NCIT_C128784 @default.
- NCIT_C107188 inSubset NCIT_C157711 @default.
- NCIT_C107188 inSubset NCIT_C157712 @default.
- NCIT_C107188 inSubset NCIT_C176424 @default.
- NCIT_C107188 inSubset NCIT_C177537 @default.
- NCIT_C107188 type Class @default.
- NCIT_C107188 isDefinedBy ncit.owl @default.
- NCIT_C107188 label "Mucoadhesive Paclitaxel Formulation" @default.
- NCIT_C107188 subClassOf NCIT_C107188 @default.
- NCIT_C107188 subClassOf NCIT_C186664 @default.
- NCIT_C107188 subClassOf NCIT_C1908 @default.
- NCIT_C107188 subClassOf NCIT_C1909 @default.
- NCIT_C107188 subClassOf NCIT_C25974 @default.
- NCIT_C107188 subClassOf NCIT_C273 @default.
- NCIT_C107188 subClassOf NCIT_C274 @default.
- NCIT_C107188 subClassOf NCIT_C61078 @default.
- NCIT_C107188 subClassOf NCIT_C67437 @default.