Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C107191> ?p ?o ?g. }
Showing items 1 to 62 of
62
with 100 items per page.
- NCIT_C107191 IAO_0000115 "Autologous human T-lymphocytes transduced with a retroviral vector encoding an anti-epidermal growth factor receptor (EGFR) chimeric T cell receptor (chimeric antigen receptor or CAR) gene coupled to the signaling domains from both CD3 zeta and CD137 (4-1BB), with potential immunostimulatory and antineoplastic activities. Upon administration, the chimeric EGFR antigen receptor-modified autologous T lymphocytes bind to the EGFR antigen on tumor cell surfaces; subsequently, EGFR-expressing tumor cells may be lysed. Following binding to EGFR, the 4-1BB co-stimulatory molecule signaling domain enhances both activation and signaling. Inclusion of the 4-1BB signaling domain may also increase the antitumor activity when compared to the inclusion of the CD3-zeta chain alone. EGFR, a receptor tyrosine kinase (RTK) overexpressed by a variety of cancer cell types, plays key roles in tumor cell proliferation and tumor angiogenesis." @default.
- NCIT_C107191 NCIT_NHC0 "C107191" @default.
- NCIT_C107191 NCIT_P106 "Cell" @default.
- NCIT_C107191 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C107191 NCIT_P108 "EGFR CAR-CD3zeta-4-1BB-expressing Autologous T-Lymphocytes" @default.
- NCIT_C107191 NCIT_P208 "CL449451" @default.
- NCIT_C107191 NCIT_P329 "750510" @default.
- NCIT_C107191 NCIT_P330 "750510" @default.
- NCIT_C107191 NCIT_P399 "750510" @default.
- NCIT_C107191 NCIT_R124 NCIT_C17828 @default.
- NCIT_C107191 NCIT_R124 NCIT_C17930 @default.
- NCIT_C107191 NCIT_R124 NCIT_C17937 @default.
- NCIT_C107191 NCIT_R124 NCIT_C18839 @default.
- NCIT_C107191 NCIT_R124 NCIT_C21124 @default.
- NCIT_C107191 NCIT_R124 NCIT_C45548 @default.
- NCIT_C107191 NCIT_R125 NCIT_C17828 @default.
- NCIT_C107191 NCIT_R125 NCIT_C17937 @default.
- NCIT_C107191 NCIT_R125 NCIT_C18095 @default.
- NCIT_C107191 NCIT_R125 NCIT_C18839 @default.
- NCIT_C107191 NCIT_R125 NCIT_C19053 @default.
- NCIT_C107191 NCIT_R125 NCIT_C21124 @default.
- NCIT_C107191 NCIT_R125 NCIT_C26280 @default.
- NCIT_C107191 NCIT_R125 NCIT_C40833 @default.
- NCIT_C107191 NCIT_R125 NCIT_C40912 @default.
- NCIT_C107191 NCIT_R72 NCIT_C104083 @default.
- NCIT_C107191 NCIT_R72 NCIT_C12219 @default.
- NCIT_C107191 NCIT_R72 NCIT_C12476 @default.
- NCIT_C107191 NCIT_R72 NCIT_C12508 @default.
- NCIT_C107191 NCIT_R72 NCIT_C12535 @default.
- NCIT_C107191 NCIT_R72 NCIT_C12542 @default.
- NCIT_C107191 NCIT_R72 NCIT_C12543 @default.
- NCIT_C107191 NCIT_R72 NCIT_C21599 @default.
- NCIT_C107191 NCIT_R72 NCIT_C32725 @default.
- NCIT_C107191 NCIT_R72 NCIT_C33061 @default.
- NCIT_C107191 NCIT_R72 NCIT_C38434 @default.
- NCIT_C107191 NCIT_R72 NCIT_C38439 @default.
- NCIT_C107191 NCIT_R72 NCIT_C39567 @default.
- NCIT_C107191 NCIT_R72 NCIT_C39568 @default.
- NCIT_C107191 normalizedInformationContent "100" @default.
- NCIT_C107191 referenceCount "1" @default.
- NCIT_C107191 hasExactSynonym "CART-EGFR TCR zeta:CD137 Cells" @default.
- NCIT_C107191 hasExactSynonym "EGFR CAR-CD3zeta-4-1BB-expressing Autologous T-Lymphocytes" @default.
- NCIT_C107191 inSubset NCIT_C128784 @default.
- NCIT_C107191 inSubset NCIT_C176424 @default.
- NCIT_C107191 type Class @default.
- NCIT_C107191 isDefinedBy ncit.owl @default.
- NCIT_C107191 label "EGFR CAR-CD3zeta-4-1BB-expressing Autologous T-Lymphocytes" @default.
- NCIT_C107191 subClassOf NCIT_C107191 @default.
- NCIT_C107191 subClassOf NCIT_C129820 @default.
- NCIT_C107191 subClassOf NCIT_C129821 @default.
- NCIT_C107191 subClassOf NCIT_C129826 @default.
- NCIT_C107191 subClassOf NCIT_C137999 @default.
- NCIT_C107191 subClassOf NCIT_C142078 @default.
- NCIT_C107191 subClassOf NCIT_C154231 @default.
- NCIT_C107191 subClassOf NCIT_C1908 @default.
- NCIT_C107191 subClassOf NCIT_C1909 @default.
- NCIT_C107191 subClassOf NCIT_C1962 @default.
- NCIT_C107191 subClassOf NCIT_C200766 @default.
- NCIT_C107191 subClassOf NCIT_C274 @default.
- NCIT_C107191 subClassOf NCIT_C28681 @default.
- NCIT_C107191 subClassOf NCIT_C307 @default.
- NCIT_C107191 subClassOf NCIT_C308 @default.