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- NCIT_C107239 IAO_0000115 "An orally available curaxin-based agent targeting the Facilitates Chromatin Transcription (FACT) complex, with potential antineoplastic activity. Upon administration, CBL0137 binds to FACT and sequesters the FACT complex on chromatin, which inhibits its activity. This prevents transcription of certain genes involved in cancer-associated signaling pathways; it specifically inhibits the transcription of both NF-kappa B and heat shock transcription factor 1 (HSF1) and simultaneously activates p53. This causes an increase in tumor cell apoptosis and a decrease in tumor cell proliferation, in FACT-positive cancers. In addition, this agent is able to sensitize FACT-positive tumor cells to the cytotoxic effects of other chemotherapeutic agents. FACT, a transcription and replication factor composed of the Structure Specific Recognition Protein (SSRP1) and suppressor of Ty 16 (Spt16) proteins, is expressed in a variety of tumor cells while almost absent in normal cells; its expression is associated with increased tumor aggressiveness and poor prognosis." @default.
- NCIT_C107239 NCIT_A32 NCIT_C1909 @default.
- NCIT_C107239 NCIT_NHC0 "C107239" @default.
- NCIT_C107239 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C107239 NCIT_P107 "FACT Complex-targeting Curaxin CBL0137" @default.
- NCIT_C107239 NCIT_P108 "FACT Complex-targeting Curaxin CBL0137" @default.
- NCIT_C107239 NCIT_P207 "C3827145" @default.
- NCIT_C107239 NCIT_P322 "CTRP" @default.
- NCIT_C107239 NCIT_P322 "GDC" @default.
- NCIT_C107239 NCIT_P329 "750614" @default.
- NCIT_C107239 NCIT_P330 "750614" @default.
- NCIT_C107239 NCIT_P375 "FACT Complex-targeting Curaxin CBL0137" @default.
- NCIT_C107239 NCIT_P399 "750614" @default.
- NCIT_C107239 NCIT_R125 NCIT_C17828 @default.
- NCIT_C107239 NCIT_R125 NCIT_C20150 @default.
- NCIT_C107239 NCIT_R125 NCIT_C20480 @default.
- NCIT_C107239 NCIT_R125 NCIT_C40715 @default.
- NCIT_C107239 NCIT_R125 NCIT_C41515 @default.
- NCIT_C107239 NCIT_R125 NCIT_C51037 @default.
- NCIT_C107239 normalizedInformationContent "100" @default.
- NCIT_C107239 referenceCount "1" @default.
- NCIT_C107239 hasExactSynonym "CBL0137" @default.
- NCIT_C107239 hasExactSynonym "FACT Complex-targeting Curaxin CBL0137" @default.
- NCIT_C107239 inSubset NCIT_C116977 @default.
- NCIT_C107239 inSubset NCIT_C116978 @default.
- NCIT_C107239 inSubset NCIT_C128784 @default.
- NCIT_C107239 inSubset NCIT_C157711 @default.
- NCIT_C107239 inSubset NCIT_C157712 @default.
- NCIT_C107239 inSubset NCIT_C176424 @default.
- NCIT_C107239 inSubset NCIT_C177537 @default.
- NCIT_C107239 type Class @default.
- NCIT_C107239 isDefinedBy ncit.owl @default.
- NCIT_C107239 label "FACT Complex-targeting Curaxin CBL0137" @default.
- NCIT_C107239 subClassOf Bb5bd7c66f113a77f8f95097dd1a32805 @default.
- NCIT_C107239 subClassOf Bdbb6fee16adb3d0fafa3f821d2971131 @default.
- NCIT_C107239 subClassOf NCIT_C107239 @default.
- NCIT_C107239 subClassOf NCIT_C1908 @default.
- NCIT_C107239 subClassOf NCIT_C1909 @default.
- NCIT_C107239 subClassOf NCIT_C2189 @default.
- NCIT_C107239 subClassOf NCIT_C274 @default.