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- NCIT_C107244 IAO_0000115 "A topical formulation containing the macrolide sirolimus (rapamycin), which is produced by the organism Streptomyces hygroscopicus, with potential anti-proliferative activity. Upon application of topical sirolimus, this agent migrates into the skin and is internalized by the affected cells. In turn, sirolimus binds to the immunophilin FK binding protein-12 (FKBP-12) and forms a sirolimus:FKBP-12 complex. This complex binds to and inhibits the activity of the serine/threonine kinase mammalian target of rapamycin (mTOR). It also decreases the production of vascular endothelial growth factor (VEGF) and results in the suppression of cellular proliferation." @default.
- NCIT_C107244 NCIT_NHC0 "C107244" @default.
- NCIT_C107244 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C107244 NCIT_P108 "Topical Sirolimus" @default.
- NCIT_C107244 NCIT_P208 "CL449498" @default.
- NCIT_C107244 NCIT_P329 "750851" @default.
- NCIT_C107244 NCIT_P330 "750851" @default.
- NCIT_C107244 NCIT_P399 "750851" @default.
- NCIT_C107244 normalizedInformationContent "100" @default.
- NCIT_C107244 referenceCount "1" @default.
- NCIT_C107244 hasExactSynonym "NPC-12G Gel" @default.
- NCIT_C107244 hasExactSynonym "NPC-12G" @default.
- NCIT_C107244 hasExactSynonym "Rapamune Topical Formulation" @default.
- NCIT_C107244 hasExactSynonym "Topical Sirolimus" @default.
- NCIT_C107244 inSubset NCIT_C176424 @default.
- NCIT_C107244 type Class @default.
- NCIT_C107244 isDefinedBy ncit.owl @default.
- NCIT_C107244 label "Topical Sirolimus" @default.
- NCIT_C107244 subClassOf NCIT_C107244 @default.
- NCIT_C107244 subClassOf NCIT_C1908 @default.
- NCIT_C107244 subClassOf NCIT_C1909 @default.
- NCIT_C107244 subClassOf NCIT_C308 @default.
- NCIT_C107244 subClassOf NCIT_C574 @default.