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- NCIT_C107386 IAO_0000115 "A phosphatidylinositol 3-kinase (PI3K) inhibitor with potential antineoplastic activity. PI3K inhibitor WX-037 specifically inhibits PI3K, which prevents the activation of the PI3K/protein kinase B-mediated signaling pathway. This may result in the inhibition of both tumor cell growth and survival in PI3K-overexpressing tumor cells. Activation of the PI3K signaling pathway is frequently associated with tumorigenesis. Dysregulated PI3K signaling may contribute to tumor resistance to a variety of antineoplastic agents." @default.
- NCIT_C107386 NCIT_A32 NCIT_C1909 @default.
- NCIT_C107386 NCIT_A7 NCIT_C17270 @default.
- NCIT_C107386 NCIT_NHC0 "C107386" @default.
- NCIT_C107386 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C107386 NCIT_P108 "PI3K Inhibitor WX-037" @default.
- NCIT_C107386 NCIT_P208 "CL449597" @default.
- NCIT_C107386 NCIT_P322 "GDC" @default.
- NCIT_C107386 NCIT_P329 "750893" @default.
- NCIT_C107386 NCIT_P330 "750893" @default.
- NCIT_C107386 NCIT_P375 "PI3K Inhibitor WX-037" @default.
- NCIT_C107386 NCIT_P399 "750893" @default.
- NCIT_C107386 normalizedInformationContent "100" @default.
- NCIT_C107386 referenceCount "1" @default.
- NCIT_C107386 hasExactSynonym "PI3K Inhibitor WX-037" @default.
- NCIT_C107386 hasExactSynonym "WX-037" @default.
- NCIT_C107386 inSubset NCIT_C128784 @default.
- NCIT_C107386 inSubset NCIT_C157711 @default.
- NCIT_C107386 inSubset NCIT_C157712 @default.
- NCIT_C107386 inSubset NCIT_C176424 @default.
- NCIT_C107386 inSubset NCIT_C177537 @default.
- NCIT_C107386 type Class @default.
- NCIT_C107386 isDefinedBy ncit.owl @default.
- NCIT_C107386 label "PI3K Inhibitor WX-037" @default.
- NCIT_C107386 subClassOf NCIT_C107386 @default.
- NCIT_C107386 subClassOf NCIT_C129824 @default.
- NCIT_C107386 subClassOf NCIT_C129825 @default.
- NCIT_C107386 subClassOf NCIT_C1404 @default.
- NCIT_C107386 subClassOf NCIT_C163758 @default.
- NCIT_C107386 subClassOf NCIT_C1742 @default.
- NCIT_C107386 subClassOf NCIT_C1908 @default.
- NCIT_C107386 subClassOf NCIT_C1909 @default.
- NCIT_C107386 subClassOf NCIT_C2152 @default.
- NCIT_C107386 subClassOf NCIT_C2189 @default.
- NCIT_C107386 subClassOf NCIT_C274 @default.
- NCIT_C107386 subClassOf NCIT_C471 @default.