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- NCIT_C107387 IAO_0000115 "A combination agent composed of the benzo-poly-carbonic-acid polymer BP-Cx1 chelated to platinum with potential antineoplastic activity. Upon intramuscular injection, the polymer moiety of BP-Cx1-Platinum Complex BP-C1 (BP-C1) alters the permeability of the cell membranes, which allows for increased penetration of platinum into tumor cells. In turn, platinum binds to nucleophilic groups such as GC-rich sites in DNA and induces intrastrand and interstrand DNA cross-links, as well as DNA-protein cross-links. These cross-links result in apoptosis and cell growth inhibition. In addition, the BP-Cx1 ligand is able to stimulate the innate immune system and upregulates a variety of cytokines including interferon, tumor necrosis factor-alpha (TNF-alpha), granulocyte macrophage-colony stimulating factor (GM-CSF), and various interleukins (ILs) such as IL-6 and IL-25. In comparison to cisplatin and other platinum-based compounds, treatment with BP-C1 allows for less platinum administration, which reduces platinum-associated systemic toxicity and side effects, and enhances the safety profile while maintaining or improving its efficacy." @default.
- NCIT_C107387 NCIT_A32 NCIT_C1909 @default.
- NCIT_C107387 NCIT_NHC0 "C107387" @default.
- NCIT_C107387 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C107387 NCIT_P108 "BP-Cx1-Platinum Complex BP-C1" @default.
- NCIT_C107387 NCIT_P208 "CL449598" @default.
- NCIT_C107387 NCIT_P322 "GDC" @default.
- NCIT_C107387 NCIT_P329 "751002" @default.
- NCIT_C107387 NCIT_P330 "751002" @default.
- NCIT_C107387 NCIT_P375 "BP-Cx1-Platinum Complex BP-C1" @default.
- NCIT_C107387 NCIT_P399 "751002" @default.
- NCIT_C107387 normalizedInformationContent "100" @default.
- NCIT_C107387 referenceCount "1" @default.
- NCIT_C107387 hasExactSynonym "BP-C1" @default.
- NCIT_C107387 hasExactSynonym "BP-Cx1-Platinum Complex BP-C1" @default.
- NCIT_C107387 inSubset NCIT_C128784 @default.
- NCIT_C107387 inSubset NCIT_C157711 @default.
- NCIT_C107387 inSubset NCIT_C157712 @default.
- NCIT_C107387 inSubset NCIT_C176424 @default.
- NCIT_C107387 inSubset NCIT_C177537 @default.
- NCIT_C107387 type Class @default.
- NCIT_C107387 isDefinedBy ncit.owl @default.
- NCIT_C107387 label "BP-Cx1-Platinum Complex BP-C1" @default.
- NCIT_C107387 subClassOf NCIT_C107387 @default.
- NCIT_C107387 subClassOf NCIT_C1450 @default.
- NCIT_C107387 subClassOf NCIT_C1590 @default.
- NCIT_C107387 subClassOf NCIT_C186664 @default.
- NCIT_C107387 subClassOf NCIT_C1908 @default.
- NCIT_C107387 subClassOf NCIT_C1909 @default.
- NCIT_C107387 subClassOf NCIT_C2163 @default.
- NCIT_C107387 subClassOf NCIT_C274 @default.
- NCIT_C107387 subClassOf NCIT_C2842 @default.
- NCIT_C107387 subClassOf NCIT_C798 @default.