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- NCIT_C107388 IAO_0000115 "An antibody-drug conjugate composed of an antibody directed against 5T4 and conjugated, via the stable linker maleimidocaproyl (mc), to the microtubule inhibitor monomethyl auristatin phenylalanine (MMAF), with potential antineoplastic activity. Upon administration, the antibody moiety of PF-06263507 selectively binds to cells expressing the 5T4 oncofetal antigen. After internalization and enzymatic cleavage of the immunoconjugate within the tumor cell cytosol, free MMAF binds to tubulin and inhibits its polymerization, which may result in G2/M phase arrest and tumor cell apoptosis. 5T4, a transmembrane glycoprotein, is overexpressed by a variety of cancer cell types; its expression is correlated with increased invasiveness." @default.
- NCIT_C107388 NCIT_A32 NCIT_C1909 @default.
- NCIT_C107388 NCIT_NHC0 "C107388" @default.
- NCIT_C107388 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C107388 NCIT_P107 "Anti-5T4 Antibody-Drug Conjugate PF-06263507" @default.
- NCIT_C107388 NCIT_P108 "Anti-5T4 Antibody-Drug Conjugate PF-06263507" @default.
- NCIT_C107388 NCIT_P208 "CL449599" @default.
- NCIT_C107388 NCIT_P319 "V7U0JSO7FH" @default.
- NCIT_C107388 NCIT_P322 "CTRP" @default.
- NCIT_C107388 NCIT_P322 "FDA" @default.
- NCIT_C107388 NCIT_P322 "GDC" @default.
- NCIT_C107388 NCIT_P329 "751006" @default.
- NCIT_C107388 NCIT_P330 "751006" @default.
- NCIT_C107388 NCIT_P375 "Anti-5T4 Antibody-Drug Conjugate PF-06263507" @default.
- NCIT_C107388 NCIT_P399 "751006" @default.
- NCIT_C107388 normalizedInformationContent "100" @default.
- NCIT_C107388 referenceCount "1" @default.
- NCIT_C107388 hasExactSynonym "Anti-5T4 Antibody-Drug Conjugate PF-06263507" @default.
- NCIT_C107388 hasExactSynonym "PF-06263507" @default.
- NCIT_C107388 inSubset NCIT_C116977 @default.
- NCIT_C107388 inSubset NCIT_C116978 @default.
- NCIT_C107388 inSubset NCIT_C128784 @default.
- NCIT_C107388 inSubset NCIT_C157711 @default.
- NCIT_C107388 inSubset NCIT_C157712 @default.
- NCIT_C107388 inSubset NCIT_C176424 @default.
- NCIT_C107388 inSubset NCIT_C177537 @default.
- NCIT_C107388 inSubset NCIT_C63923 @default.
- NCIT_C107388 type Class @default.
- NCIT_C107388 isDefinedBy ncit.owl @default.
- NCIT_C107388 label "Anti-5T4 Antibody-Drug Conjugate PF-06263507" @default.
- NCIT_C107388 subClassOf NCIT_C107388 @default.
- NCIT_C107388 subClassOf NCIT_C129821 @default.
- NCIT_C107388 subClassOf NCIT_C129823 @default.
- NCIT_C107388 subClassOf NCIT_C1512 @default.
- NCIT_C107388 subClassOf NCIT_C1908 @default.
- NCIT_C107388 subClassOf NCIT_C1909 @default.
- NCIT_C107388 subClassOf NCIT_C274 @default.
- NCIT_C107388 subClassOf NCIT_C307 @default.
- NCIT_C107388 subClassOf NCIT_C308 @default.