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- NCIT_C107422 IAO_0000115 "DDB1- and CUL4-associated factor 1 (1507 aa, ~169 kDa) is encoded by the human DCAF1 gene. This protein plays a role in both serine/threonine-protein kinase activity and E3 ubiquitin-protein ligase complex substrate recognition." @default.
- NCIT_C107422 NCIT_NHC0 "C107422" @default.
- NCIT_C107422 NCIT_P100 "617259" @default.
- NCIT_C107422 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C107422 NCIT_P106 "Enzyme" @default.
- NCIT_C107422 NCIT_P107 "DDB1- and CUL4-Associated Factor 1" @default.
- NCIT_C107422 NCIT_P108 "DDB1- and CUL4-Associated Factor 1" @default.
- NCIT_C107422 NCIT_P207 "C2355557" @default.
- NCIT_C107422 NCIT_P322 "CTRP" @default.
- NCIT_C107422 NCIT_P93 "Q9Y4B6" @default.
- NCIT_C107422 NCIT_P98 "DDB1- and CUL4-associated factor 1 binds the HIV-1 protein Vpr. This binding protects Vpr from proteosomal degradation and promotes the ubiquitination and degradation of endogenous proteins, which leads to G2 phase cell cycle arrest. (UniProt)" @default.
- NCIT_C107422 NCIT_P98 "DDB1- and CUL4-associated factor 1 binds to the HIV-2 protein Vpx, which enhances macrophage infectivity of the virus. (UniProt)" @default.
- NCIT_C107422 NCIT_P98 "DDB1- and CUL4-associated factor 1 has atypical serine/threonine-protein kinase activity that specifically phosphorylates the threonine at amino acid position 120 of histone H2A (H2AT120ph). H2AT120ph is associated with repression of gene transcription. (UniProt)" @default.
- NCIT_C107422 NCIT_P98 "DDB1- and CUL4-associated factor 1 is a component of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex, specifically the CUL4A-RBX1-DDB1-DCAF1/VPRBP complex. (UniProt)" @default.
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- NCIT_C107422 normalizedInformationContent "100" @default.
- NCIT_C107422 referenceCount "1" @default.
- NCIT_C107422 hasExactSynonym "DCAF1" @default.
- NCIT_C107422 hasExactSynonym "DDB1 and CUL4 Associated Factor 1" @default.
- NCIT_C107422 hasExactSynonym "DDB1- and CUL4-Associated Factor 1" @default.
- NCIT_C107422 hasExactSynonym "EC 2.7.11.1" @default.
- NCIT_C107422 hasExactSynonym "HIV-1 Vpr-Binding Protein" @default.
- NCIT_C107422 hasExactSynonym "Protein VPRBP" @default.
- NCIT_C107422 hasExactSynonym "Serine/Threonine-Protein Kinase VPRBP" @default.
- NCIT_C107422 hasExactSynonym "Vpr-Binding Protein" @default.
- NCIT_C107422 hasExactSynonym "Vpr-Interacting Protein" @default.
- NCIT_C107422 inSubset NCIT_C116977 @default.
- NCIT_C107422 inSubset NCIT_C142799 @default.
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- NCIT_C107422 type Class @default.
- NCIT_C107422 isDefinedBy ncit.owl @default.
- NCIT_C107422 label "DDB1- and CUL4-Associated Factor 1" @default.
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