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- NCIT_C107503 IAO_0000115 "A fusion protein complex composed of a mutated form of the cytokine interleukin (IL)-15 (IL-15N72D) and a soluble, dimeric IL-15 receptor alpha (IL-15Ra) Fc fusion protein (IL-15Ra-Fc) (IL-15N72D/IL-15Ra-Fc), with potential antineoplastic activity. Upon administration, superagonist interleukin-15:interleukin-15 receptor alphaSu/Fc fusion complex N-803 binds to the IL-2/IL-15 receptor beta-common gamma chain (IL-2Rbetagamma) receptor on natural killer (NK) and CD8+ T lymphocytes, which activates and increases the levels of NK cells and memory CD8+(CD44high) T-cells. The memory T-cells enhance the secretion of the cytokine interferon-gamma (IFN-g), which further potentiates the immune response against tumor cells. This may increase tumor cell killing and decrease tumor cell proliferation. IL-15 regulates CD8+ T and NK cell development, activation and proliferation. By coupling IL-15 to IL15Ra-Fc, this agent has a prolonged drug half-life and shows an increased ability to bind IL-2Rbetagamma, which enhances its immune stimulatory activity as compared to IL-15 alone." @default.
- NCIT_C107503 NCIT_A32 NCIT_C1909 @default.
- NCIT_C107503 NCIT_NHC0 "C107503" @default.
- NCIT_C107503 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C107503 NCIT_P107 "Nogapendekin Alfa" @default.
- NCIT_C107503 NCIT_P108 "Nogapendekin Alfa" @default.
- NCIT_C107503 NCIT_P207 "C3658787" @default.
- NCIT_C107503 NCIT_P210 "1622189-43-8" @default.
- NCIT_C107503 NCIT_P210 "1850381-92-8 (ALT-803)" @default.
- NCIT_C107503 NCIT_P319 "7TK323DLA0" @default.
- NCIT_C107503 NCIT_P322 "CTRP" @default.
- NCIT_C107503 NCIT_P322 "FDA" @default.
- NCIT_C107503 NCIT_P322 "GDC" @default.
- NCIT_C107503 NCIT_P329 "751380" @default.
- NCIT_C107503 NCIT_P330 "751380" @default.
- NCIT_C107503 NCIT_P375 "Nogapendekin Alfa" @default.
- NCIT_C107503 NCIT_P375 "Superagonist Interleukin-15:Interleukin-15 Receptor alphaSu/Fc Fusion Complex ALT-803" @default.
- NCIT_C107503 NCIT_P399 "751380" @default.
- NCIT_C107503 normalizedInformationContent "100" @default.
- NCIT_C107503 referenceCount "1" @default.
- NCIT_C107503 hasExactSynonym "ALT 803" @default.
- NCIT_C107503 hasExactSynonym "ALT-803" @default.
- NCIT_C107503 hasExactSynonym "ALT803" @default.
- NCIT_C107503 hasExactSynonym "Fusion Protein Consisting of IL-15N72D and IL-15RaSu/FC" @default.
- NCIT_C107503 hasExactSynonym "IL-15N72D/IL-15Ra-Fc" @default.
- NCIT_C107503 hasExactSynonym "IL-15N72D:IL-15RaSu/Fc Fusion Complex" @default.
- NCIT_C107503 hasExactSynonym "N 803" @default.
- NCIT_C107503 hasExactSynonym "N-803" @default.
- NCIT_C107503 hasExactSynonym "N803" @default.
- NCIT_C107503 hasExactSynonym "NOGAPENDEKIN ALFA" @default.
- NCIT_C107503 hasExactSynonym "Nogapendekin Alfa" @default.
- NCIT_C107503 hasExactSynonym "Superagonist Interleukin-15:Interleukin-15 Receptor AlphaSu/Fc Fusion Complex Alt-803" @default.
- NCIT_C107503 inSubset NCIT_C116977 @default.
- NCIT_C107503 inSubset NCIT_C116978 @default.
- NCIT_C107503 inSubset NCIT_C128784 @default.
- NCIT_C107503 inSubset NCIT_C157711 @default.
- NCIT_C107503 inSubset NCIT_C157712 @default.
- NCIT_C107503 inSubset NCIT_C173381 @default.
- NCIT_C107503 inSubset NCIT_C173383 @default.
- NCIT_C107503 inSubset NCIT_C176424 @default.
- NCIT_C107503 inSubset NCIT_C177537 @default.
- NCIT_C107503 inSubset NCIT_C63923 @default.
- NCIT_C107503 type Class @default.
- NCIT_C107503 isDefinedBy ncit.owl @default.
- NCIT_C107503 label "Nogapendekin Alfa" @default.
- NCIT_C107503 subClassOf NCIT_C107503 @default.
- NCIT_C107503 subClassOf NCIT_C129820 @default.
- NCIT_C107503 subClassOf NCIT_C129821 @default.
- NCIT_C107503 subClassOf NCIT_C1908 @default.
- NCIT_C107503 subClassOf NCIT_C1909 @default.
- NCIT_C107503 subClassOf NCIT_C274 @default.
- NCIT_C107503 subClassOf NCIT_C307 @default.
- NCIT_C107503 subClassOf NCIT_C308 @default.