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- NCIT_C107504 IAO_0000115 "A replication selective, recombinant, E1B and partial E3 gene deleted form of human adenovirus type 5, with potential antineoplastic activity. Upon intratumoral injection of recombinant human adenovirus type 5, the adenovirus selectively replicates in cancer cells while preventing viral replication in normal, healthy cells. This induces a selective adenovirus-mediated cytotoxicity in cancer cells, which leads to cancer cell lysis. In addition, viral spread to adjacent cells, following lysis of infected cells, may activate the immune system to kill the infected tumor cells. The E1B protein causes p53 inactivation, which promotes viral replication; deletion of E1B allows for p53 activation in normal cells, which prevents viral replication in normal, healthy cells. The mutation and subsequent inactivation of p53 in cancer cells enables the E1B-deleted adenovirus to selectively replicate in cancer cells. Partial deletion of E3, encoding the adenovirus death protein, enhances the safety profile of the administered adenovirus." @default.
- NCIT_C107504 NCIT_A32 NCIT_C1909 @default.
- NCIT_C107504 NCIT_NHC0 "C107504" @default.
- NCIT_C107504 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C107504 NCIT_P108 "Recombinant Human Adenovirus Type 5 H101" @default.
- NCIT_C107504 NCIT_P208 "CL451750" @default.
- NCIT_C107504 NCIT_P210 "1802358-15-1" @default.
- NCIT_C107504 NCIT_P319 "QH36X20ODG" @default.
- NCIT_C107504 NCIT_P322 "FDA" @default.
- NCIT_C107504 NCIT_P322 "GDC" @default.
- NCIT_C107504 NCIT_P329 "751381" @default.
- NCIT_C107504 NCIT_P330 "751381" @default.
- NCIT_C107504 NCIT_P375 "Recombinant Human Adenovirus Type 5 H101" @default.
- NCIT_C107504 NCIT_P399 "751381" @default.
- NCIT_C107504 normalizedInformationContent "100" @default.
- NCIT_C107504 referenceCount "1" @default.
- NCIT_C107504 hasExactSynonym "H-101" @default.
- NCIT_C107504 hasExactSynonym "H101" @default.
- NCIT_C107504 hasExactSynonym "Oncorine" @default.
- NCIT_C107504 hasExactSynonym "Recombinant Human Adenovirus Type 5 H101" @default.
- NCIT_C107504 hasExactSynonym "rAd5 H101" @default.
- NCIT_C107504 inSubset NCIT_C128784 @default.
- NCIT_C107504 inSubset NCIT_C157711 @default.
- NCIT_C107504 inSubset NCIT_C157712 @default.
- NCIT_C107504 inSubset NCIT_C176424 @default.
- NCIT_C107504 inSubset NCIT_C177537 @default.
- NCIT_C107504 inSubset NCIT_C63923 @default.
- NCIT_C107504 type Class @default.
- NCIT_C107504 isDefinedBy ncit.owl @default.
- NCIT_C107504 label "Recombinant Human Adenovirus Type 5 H101" @default.
- NCIT_C107504 subClassOf NCIT_C107504 @default.
- NCIT_C107504 subClassOf NCIT_C129821 @default.
- NCIT_C107504 subClassOf NCIT_C1908 @default.
- NCIT_C107504 subClassOf NCIT_C1909 @default.
- NCIT_C107504 subClassOf NCIT_C274 @default.
- NCIT_C107504 subClassOf NCIT_C307 @default.
- NCIT_C107504 subClassOf NCIT_C717 @default.