Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C107505> ?p ?o ?g. }
Showing items 1 to 36 of
36
with 100 items per page.
- NCIT_C107505 IAO_0000115 "T-lymphocytes transduced with a retroviral vector expressing a chimeric antigen receptor (CAR) specific for syndecan-1 (CD138) (CART-138 T cells) coupled to the signaling domain of 4-1BB (CD137), and the zeta chain of the T-cell receptor (TCRzeta), with potential immunomodulating and antineoplastic activities. Upon transfusion, CD138CAR- CD137/TCRzeta -expressing T lymphocytes directs the T-lymphocytes to syndecan-1-expressing tumor cells and induces selective toxicity in those tumor cells. The 4-1BB co-stimulatory molecule signaling domain enhances activation and signaling after recognition of syndecan-1. Syndecan-1, a type 1 transmembrane proteoglycan and tumor associated antigen, is overexpressed in a variety of cancer cells. It plays a key role in the regulation of cell growth, differentiation, and adhesion, and its expression is correlated with poor prognosis." @default.
- NCIT_C107505 NCIT_A7 NCIT_C96914 @default.
- NCIT_C107505 NCIT_NHC0 "C107505" @default.
- NCIT_C107505 NCIT_P106 "Cell" @default.
- NCIT_C107505 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C107505 NCIT_P107 "CD138CAR-CD137/TCRzeta-expressing T Lymphocytes" @default.
- NCIT_C107505 NCIT_P108 "CD138CAR-CD137/TCRzeta-expressing T Lymphocytes" @default.
- NCIT_C107505 NCIT_P208 "CL451751" @default.
- NCIT_C107505 NCIT_P322 "CTRP" @default.
- NCIT_C107505 NCIT_P329 "751382" @default.
- NCIT_C107505 NCIT_P330 "751382" @default.
- NCIT_C107505 NCIT_P399 "751382" @default.
- NCIT_C107505 normalizedInformationContent "100" @default.
- NCIT_C107505 referenceCount "1" @default.
- NCIT_C107505 hasExactSynonym "CART-138 TCR zeta:CD137" @default.
- NCIT_C107505 hasExactSynonym "CD138CAR-CD137/TCRzeta-expressing T Lymphocytes" @default.
- NCIT_C107505 inSubset NCIT_C116977 @default.
- NCIT_C107505 inSubset NCIT_C116978 @default.
- NCIT_C107505 inSubset NCIT_C128784 @default.
- NCIT_C107505 inSubset NCIT_C176424 @default.
- NCIT_C107505 type Class @default.
- NCIT_C107505 isDefinedBy ncit.owl @default.
- NCIT_C107505 label "CD138CAR-CD137/TCRzeta-expressing T Lymphocytes" @default.
- NCIT_C107505 subClassOf NCIT_C107505 @default.
- NCIT_C107505 subClassOf NCIT_C129820 @default.
- NCIT_C107505 subClassOf NCIT_C129821 @default.
- NCIT_C107505 subClassOf NCIT_C129826 @default.
- NCIT_C107505 subClassOf NCIT_C137999 @default.
- NCIT_C107505 subClassOf NCIT_C142078 @default.
- NCIT_C107505 subClassOf NCIT_C154231 @default.
- NCIT_C107505 subClassOf NCIT_C1908 @default.
- NCIT_C107505 subClassOf NCIT_C1909 @default.
- NCIT_C107505 subClassOf NCIT_C1962 @default.
- NCIT_C107505 subClassOf NCIT_C274 @default.
- NCIT_C107505 subClassOf NCIT_C307 @default.
- NCIT_C107505 subClassOf NCIT_C308 @default.