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- NCIT_C107506 IAO_0000115 "An orally available, small molecule selective and S-adenosyl methionine (SAM) competitive inhibitor of histone methyl transferase EZH2, with potential antineoplastic activity. Upon oral administration, tazemetostat selectively inhibits the activity of both wild-type and mutated forms of EZH2. Inhibition of EZH2 specifically prevents the methylation of histone H3 lysine 27 (H3K27). This decrease in histone methylation alters gene expression patterns associated with cancer pathways and results in decreased tumor cell proliferation in EZH2 mutated cancer cells. EZH2, which belongs to the class of histone methyltransferases (HMTs), is overexpressed or mutated in a variety of cancer cells and plays a key role in tumor cell proliferation." @default.
- NCIT_C107506 NCIT_A32 NCIT_C1909 @default.
- NCIT_C107506 NCIT_A7 NCIT_C30175 @default.
- NCIT_C107506 NCIT_NHC0 "C107506" @default.
- NCIT_C107506 NCIT_P106 "Organic Chemical" @default.
- NCIT_C107506 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C107506 NCIT_P107 "Tazemetostat" @default.
- NCIT_C107506 NCIT_P108 "Tazemetostat" @default.
- NCIT_C107506 NCIT_P207 "C3827128" @default.
- NCIT_C107506 NCIT_P210 "1403254-99-8" @default.
- NCIT_C107506 NCIT_P319 "Q40W93WPE1" @default.
- NCIT_C107506 NCIT_P322 "CTRP" @default.
- NCIT_C107506 NCIT_P322 "FDA" @default.
- NCIT_C107506 NCIT_P322 "GDC" @default.
- NCIT_C107506 NCIT_P375 "Tazemetostat" @default.
- NCIT_C107506 normalizedInformationContent "100" @default.
- NCIT_C107506 referenceCount "1" @default.
- NCIT_C107506 hasExactSynonym "E7438" @default.
- NCIT_C107506 hasExactSynonym "EPZ-6438" @default.
- NCIT_C107506 hasExactSynonym "EPZ6438" @default.
- NCIT_C107506 hasExactSynonym "N-((4,6-Dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl(oxan-4-yl)amino)-4-methyl-4'-((morpholin-4-yl)methyl)(1,1'-biphenyl)-3-carboxamide" @default.
- NCIT_C107506 hasExactSynonym "N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-4-methyl-4'-(morpholinomethyl)-[1,1'-biphenyl]-3-carboxamide" @default.
- NCIT_C107506 hasExactSynonym "TAZEMETOSTAT" @default.
- NCIT_C107506 hasExactSynonym "Tazemetostat" @default.
- NCIT_C107506 inSubset NCIT_C116977 @default.
- NCIT_C107506 inSubset NCIT_C116978 @default.
- NCIT_C107506 inSubset NCIT_C128784 @default.
- NCIT_C107506 inSubset NCIT_C157711 @default.
- NCIT_C107506 inSubset NCIT_C157712 @default.
- NCIT_C107506 inSubset NCIT_C177537 @default.
- NCIT_C107506 inSubset NCIT_C63923 @default.
- NCIT_C107506 type Class @default.
- NCIT_C107506 isDefinedBy ncit.owl @default.
- NCIT_C107506 label "Tazemetostat" @default.
- NCIT_C107506 subClassOf NCIT_C107506 @default.
- NCIT_C107506 subClassOf NCIT_C129824 @default.
- NCIT_C107506 subClassOf NCIT_C129825 @default.
- NCIT_C107506 subClassOf NCIT_C156804 @default.
- NCIT_C107506 subClassOf NCIT_C1908 @default.
- NCIT_C107506 subClassOf NCIT_C1909 @default.
- NCIT_C107506 subClassOf NCIT_C2189 @default.
- NCIT_C107506 subClassOf NCIT_C274 @default.
- NCIT_C107506 subClassOf NCIT_C471 @default.