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- NCIT_C107676 IAO_0000115 "A third-generation, supramolecular platinum-based compound composed of carboplatin linked, by a strong hydrogen bond, to 1,1-cyclobutane dicarboxylate (CBDCA), with potential antineoplastic activity. Although the exact mechanism of action has yet to be fully elucidated, dicycloplatin appears to have a mechanism of action similar to that of other platinum-based compounds, which involves both DNA binding and the formation of DNA crosslinks. This mechanism results in the induction of apoptosis and cell growth inhibition. Compared to carboplatin alone, dicycloplatin shows enhanced solubility and stability in aqueous solution and appears to have a more favorable toxicity profile." @default.
- NCIT_C107676 NCIT_A32 NCIT_C1909 @default.
- NCIT_C107676 NCIT_NHC0 "C107676" @default.
- NCIT_C107676 NCIT_P106 "Organic Chemical" @default.
- NCIT_C107676 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C107676 NCIT_P108 "Dicycloplatin" @default.
- NCIT_C107676 NCIT_P207 "C3815135" @default.
- NCIT_C107676 NCIT_P210 "287402-09-9" @default.
- NCIT_C107676 NCIT_P319 "0KC57I4UNB" @default.
- NCIT_C107676 NCIT_P322 "FDA" @default.
- NCIT_C107676 NCIT_P322 "GDC" @default.
- NCIT_C107676 NCIT_P375 "Dicycloplatin" @default.
- NCIT_C107676 normalizedInformationContent "100" @default.
- NCIT_C107676 referenceCount "1" @default.
- NCIT_C107676 hasExactSynonym "DCP" @default.
- NCIT_C107676 hasExactSynonym "DICYCLOPLATIN" @default.
- NCIT_C107676 hasExactSynonym "Dicycloplatin" @default.
- NCIT_C107676 inSubset NCIT_C128784 @default.
- NCIT_C107676 inSubset NCIT_C157711 @default.
- NCIT_C107676 inSubset NCIT_C157712 @default.
- NCIT_C107676 inSubset NCIT_C177537 @default.
- NCIT_C107676 inSubset NCIT_C63923 @default.
- NCIT_C107676 type Class @default.
- NCIT_C107676 isDefinedBy ncit.owl @default.
- NCIT_C107676 label "Dicycloplatin" @default.
- NCIT_C107676 subClassOf NCIT_C107676 @default.
- NCIT_C107676 subClassOf NCIT_C1450 @default.
- NCIT_C107676 subClassOf NCIT_C1590 @default.
- NCIT_C107676 subClassOf NCIT_C186664 @default.
- NCIT_C107676 subClassOf NCIT_C1908 @default.
- NCIT_C107676 subClassOf NCIT_C1909 @default.
- NCIT_C107676 subClassOf NCIT_C2163 @default.
- NCIT_C107676 subClassOf NCIT_C274 @default.
- NCIT_C107676 subClassOf NCIT_C2842 @default.
- NCIT_C107676 subClassOf NCIT_C798 @default.