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- NCIT_C107680 IAO_0000115 "A peptide-drug conjugate composed of a peptide conjugated, via an aminopeptidase-targeting linkage, to the alkylating agent melphalan, with potential antineoplastic and anti-angiogenic activities. Upon administration, the highly lipophilic melphalan flufenamide penetrates cell membranes and enters cells. In aminopeptidase-positive tumor cells, melphalan flufenamide is hydrolyzed by peptidases to release the hydrophilic alkylating agent melphalan. This results in the specific release and accumulation of melphalan in aminopeptidase-positive tumor cells. Melphalan alkylates DNA at the N7 position of guanine residues and induces DNA intra- and inter-strand cross-linkages. This results in the inhibition of DNA and RNA synthesis and the induction of apoptosis, thereby inhibiting tumor cell proliferation. Peptidases are overexpressed by certain cancer cells. The administration of melphalan flufenamide allows for enhanced efficacy and reduced toxicity compared to melphalan." @default.
- NCIT_C107680 NCIT_A32 NCIT_C1909 @default.
- NCIT_C107680 NCIT_NHC0 "C107680" @default.
- NCIT_C107680 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C107680 NCIT_P107 "Melphalan Flufenamide" @default.
- NCIT_C107680 NCIT_P108 "Melphalan Flufenamide" @default.
- NCIT_C107680 NCIT_P207 "C1435750" @default.
- NCIT_C107680 NCIT_P210 "380449-51-4" @default.
- NCIT_C107680 NCIT_P319 "F70C5K4786" @default.
- NCIT_C107680 NCIT_P322 "CTRP" @default.
- NCIT_C107680 NCIT_P322 "FDA" @default.
- NCIT_C107680 NCIT_P322 "GDC" @default.
- NCIT_C107680 NCIT_P329 "751473" @default.
- NCIT_C107680 NCIT_P330 "751473" @default.
- NCIT_C107680 NCIT_P375 "Melphalan Flufenamide" @default.
- NCIT_C107680 NCIT_P399 "751473" @default.
- NCIT_C107680 normalizedInformationContent "95.413332725061409" @default.
- NCIT_C107680 referenceCount "2" @default.
- NCIT_C107680 hasExactSynonym "Ethyl (2S)-2-((2S)-2-Amino-3-(4-(bis(2-chloroethyl)amino)phenyl)propanamido)-3-(4-fluorophenyl)propanoate" @default.
- NCIT_C107680 hasExactSynonym "J-1" @default.
- NCIT_C107680 hasExactSynonym "J1" @default.
- NCIT_C107680 hasExactSynonym "L-melphalanyl-p-L-fluorophenylalanine Ethyl Ester" @default.
- NCIT_C107680 hasExactSynonym "MELPHALAN FLUFENAMIDE" @default.
- NCIT_C107680 hasExactSynonym "Melflufen" @default.
- NCIT_C107680 hasExactSynonym "Melphalan Flufenamide" @default.
- NCIT_C107680 hasExactSynonym "Prodrug J1" @default.
- NCIT_C107680 hasExactSynonym "Ygalo" @default.
- NCIT_C107680 inSubset NCIT_C116977 @default.
- NCIT_C107680 inSubset NCIT_C116978 @default.
- NCIT_C107680 inSubset NCIT_C128784 @default.
- NCIT_C107680 inSubset NCIT_C157711 @default.
- NCIT_C107680 inSubset NCIT_C157712 @default.
- NCIT_C107680 inSubset NCIT_C176424 @default.
- NCIT_C107680 inSubset NCIT_C177537 @default.
- NCIT_C107680 inSubset NCIT_C63923 @default.
- NCIT_C107680 type Class @default.
- NCIT_C107680 isDefinedBy ncit.owl @default.
- NCIT_C107680 label "Melphalan Flufenamide" @default.
- NCIT_C107680 subClassOf NCIT_C107680 @default.
- NCIT_C107680 subClassOf NCIT_C1590 @default.
- NCIT_C107680 subClassOf NCIT_C1742 @default.
- NCIT_C107680 subClassOf NCIT_C186664 @default.
- NCIT_C107680 subClassOf NCIT_C1908 @default.
- NCIT_C107680 subClassOf NCIT_C1909 @default.
- NCIT_C107680 subClassOf NCIT_C2114 @default.
- NCIT_C107680 subClassOf NCIT_C274 @default.
- NCIT_C107680 subClassOf NCIT_C2842 @default.
- NCIT_C107680 subClassOf NCIT_C697 @default.