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- NCIT_C107681 IAO_0000115 "An off-the-shelf (OTS) autophagosome-enriched tumor vaccine composed of dendritic cell (DC)-targeting microvesicles containing short lived proteins (SLiPs) and defective ribosomal products (DRiPs) derived from tumor cells, with potential immunostimulating and antineoplastic activities. The DriPs- and SLiPs-filled autophagosome microvesicles are made by treating two human non-small cell lung cancer (NSCLC) cell lines, UbiLT3 (non-specific histopathology) and UbiLT6 (adenocarcinoma-like) with both a proteasome inhibitor, to prevent protein degradation, and an autophagy inducer. DPV-001 contains a wide variety of NSCLC-derived TAAs, many as immunogenic altered-peptide ligands (APL), and numerous damage-associated molecular pattern molecules (DAMPs) with Toll-like receptor (TLR) 2, 3, 4, 7 and 9 agonist activities. Upon administration of allogeneic autophagosome-enriched vaccine DPV-001, the proteins in the vaccine target DCs and may stimulate the immune system to mount cytotoxic T-lymphocyte (CTL) and helper T-lymphocyte responses against the TAAs. The TAAs are overexpressed in a variety of cancer cell types other than NSCLC. The tumor-associated SLiPS and DRiPs are highly unstable and normally degraded by tumor cell proteasomes. They are typically not processed and cross-presented by antigen-presenting cells (APCs)." @default.
- NCIT_C107681 NCIT_NHC0 "C107681" @default.
- NCIT_C107681 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C107681 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C107681 NCIT_P107 "Allogeneic Autophagosome-enriched Vaccine DPV-001" @default.
- NCIT_C107681 NCIT_P108 "Allogeneic Autophagosome-enriched Vaccine DPV-001" @default.
- NCIT_C107681 NCIT_P208 "CL451870" @default.
- NCIT_C107681 NCIT_P322 "CTRP" @default.
- NCIT_C107681 NCIT_P329 "751474" @default.
- NCIT_C107681 NCIT_P330 "751474" @default.
- NCIT_C107681 NCIT_P399 "751474" @default.
- NCIT_C107681 normalizedInformationContent "100" @default.
- NCIT_C107681 referenceCount "1" @default.
- NCIT_C107681 hasExactSynonym "Allogeneic Autophagosome-enriched Vaccine DPV-001" @default.
- NCIT_C107681 hasExactSynonym "Allogeneic DRibble Vaccine DPV-001" @default.
- NCIT_C107681 hasExactSynonym "DPV 001" @default.
- NCIT_C107681 hasExactSynonym "DPV-001 Vaccine" @default.
- NCIT_C107681 hasExactSynonym "DPV-001" @default.
- NCIT_C107681 hasExactSynonym "DPV001" @default.
- NCIT_C107681 hasExactSynonym "DRiPs and SLiPs-containing Blebs Vaccine DPV-001" @default.
- NCIT_C107681 hasExactSynonym "DRibble Vaccine DPV-001" @default.
- NCIT_C107681 hasExactSynonym "Dribble Cancer Vaccine DPV-001" @default.
- NCIT_C107681 hasExactSynonym "Dribbles Vaccine DPV-001" @default.
- NCIT_C107681 hasExactSynonym "Tumor-derived Autophagosomes Vaccine DPV-001" @default.
- NCIT_C107681 hasExactSynonym "Vaccine DPV-001" @default.
- NCIT_C107681 inSubset NCIT_C116977 @default.
- NCIT_C107681 inSubset NCIT_C116978 @default.
- NCIT_C107681 inSubset NCIT_C128784 @default.
- NCIT_C107681 inSubset NCIT_C176424 @default.
- NCIT_C107681 type Class @default.
- NCIT_C107681 isDefinedBy ncit.owl @default.
- NCIT_C107681 label "Allogeneic Autophagosome-enriched Vaccine DPV-001" @default.
- NCIT_C107681 subClassOf NCIT_C107681 @default.
- NCIT_C107681 subClassOf NCIT_C129820 @default.
- NCIT_C107681 subClassOf NCIT_C1663 @default.
- NCIT_C107681 subClassOf NCIT_C1908 @default.
- NCIT_C107681 subClassOf NCIT_C1909 @default.
- NCIT_C107681 subClassOf NCIT_C274 @default.
- NCIT_C107681 subClassOf NCIT_C307 @default.
- NCIT_C107681 subClassOf NCIT_C308 @default.
- NCIT_C107681 subClassOf NCIT_C923 @default.