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- NCIT_C107682 IAO_0000115 "An agent composed of substance P (SP) conjugated to the ribosome-inactivating protein and neurotoxin saporin (SAP), isolated from the seeds of the plant Saponaria officinalis (SP-SAP), with potential analgesic activity. Upon administration, SP-SAP targets the SP receptor, neurokinin-1 receptor (NK-1R), located on neurons. When SP-SAP binds NK-1R and the receptor/conjugate complex internalizes, the saporin moiety inactivates ribosomes and prevents protein synthesis, which causes cell death, destroys NK-1R-expressing nerves and decreases pain perception." @default.
- NCIT_C107682 NCIT_NHC0 "C107682" @default.
- NCIT_C107682 NCIT_P106 "Organic Chemical" @default.
- NCIT_C107682 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C107682 NCIT_P107 "Substance P-Saporin" @default.
- NCIT_C107682 NCIT_P108 "Substance P-Saporin" @default.
- NCIT_C107682 NCIT_P207 "C1172252" @default.
- NCIT_C107682 NCIT_P322 "CTRP" @default.
- NCIT_C107682 NCIT_P329 "751578" @default.
- NCIT_C107682 NCIT_P330 "751578" @default.
- NCIT_C107682 NCIT_P399 "751578" @default.
- NCIT_C107682 normalizedInformationContent "100" @default.
- NCIT_C107682 referenceCount "1" @default.
- NCIT_C107682 hasExactSynonym "SP-SAP" @default.
- NCIT_C107682 hasExactSynonym "Substance P-Saporin" @default.
- NCIT_C107682 inSubset NCIT_C116977 @default.
- NCIT_C107682 inSubset NCIT_C116978 @default.
- NCIT_C107682 inSubset NCIT_C176424 @default.
- NCIT_C107682 type Class @default.
- NCIT_C107682 isDefinedBy ncit.owl @default.
- NCIT_C107682 label "Substance P-Saporin" @default.
- NCIT_C107682 subClassOf NCIT_C107682 @default.
- NCIT_C107682 subClassOf NCIT_C1908 @default.
- NCIT_C107682 subClassOf NCIT_C1909 @default.
- NCIT_C107682 subClassOf NCIT_C241 @default.
- NCIT_C107682 subClassOf NCIT_C78272 @default.