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- NCIT_C107686 IAO_0000115 "An orally bioavailable, selective inhibitor of the delta isoform of the 110 kDa catalytic subunit of class I phosphoinositide-3 kinases (PI3K) with potential antineoplastic activity. Dezapelisib specifically inhibits PI3Kdelta, which prevents both the production of the second messenger phosphatidylinositol-3,4,5-trisphosphate (PIP3) and the activation of the PI3K/AKT kinase signaling pathway. This decreases proliferation and induces cell death in PI3K-overexpressing tumor cells. Unlike other isoforms of PI3K, PI3Kdelta is often overexpressed in tumor cells, especially those of hematologic origin, and plays a crucial role in tumor cell regulation and survival. The targeted inhibition of PI3Kdelta allows for PI3K signaling in normal, non-neoplastic cells." @default.
- NCIT_C107686 NCIT_A32 NCIT_C1909 @default.
- NCIT_C107686 NCIT_A7 NCIT_C113631 @default.
- NCIT_C107686 NCIT_NHC0 "C107686" @default.
- NCIT_C107686 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C107686 NCIT_P107 "Dezapelisib" @default.
- NCIT_C107686 NCIT_P108 "Dezapelisib" @default.
- NCIT_C107686 NCIT_P208 "CL451874" @default.
- NCIT_C107686 NCIT_P210 "1262440-25-4" @default.
- NCIT_C107686 NCIT_P319 "2K59L7G59M" @default.
- NCIT_C107686 NCIT_P322 "CTRP" @default.
- NCIT_C107686 NCIT_P322 "FDA" @default.
- NCIT_C107686 NCIT_P322 "GDC" @default.
- NCIT_C107686 NCIT_P329 "751623" @default.
- NCIT_C107686 NCIT_P330 "751623" @default.
- NCIT_C107686 NCIT_P375 "Dezapelisib" @default.
- NCIT_C107686 NCIT_P399 "751623" @default.
- NCIT_C107686 normalizedInformationContent "100" @default.
- NCIT_C107686 referenceCount "1" @default.
- NCIT_C107686 hasExactSynonym "5H-Thiazolo(3,2-a)pyrimidin-5-one, 6-(3-Fluorophenyl)-3-methyl-7-((1S)-1-(9H-purin-6-ylamino)ethyl)-" @default.
- NCIT_C107686 hasExactSynonym "DEZAPELISIB" @default.
- NCIT_C107686 hasExactSynonym "Dezapelisib" @default.
- NCIT_C107686 hasExactSynonym "INCB040093" @default.
- NCIT_C107686 inSubset NCIT_C116977 @default.
- NCIT_C107686 inSubset NCIT_C116978 @default.
- NCIT_C107686 inSubset NCIT_C128784 @default.
- NCIT_C107686 inSubset NCIT_C157711 @default.
- NCIT_C107686 inSubset NCIT_C157712 @default.
- NCIT_C107686 inSubset NCIT_C176424 @default.
- NCIT_C107686 inSubset NCIT_C177537 @default.
- NCIT_C107686 inSubset NCIT_C63923 @default.
- NCIT_C107686 type Class @default.
- NCIT_C107686 isDefinedBy ncit.owl @default.
- NCIT_C107686 label "Dezapelisib" @default.
- NCIT_C107686 subClassOf NCIT_C107686 @default.
- NCIT_C107686 subClassOf NCIT_C129824 @default.
- NCIT_C107686 subClassOf NCIT_C129825 @default.
- NCIT_C107686 subClassOf NCIT_C1404 @default.
- NCIT_C107686 subClassOf NCIT_C163758 @default.
- NCIT_C107686 subClassOf NCIT_C1742 @default.
- NCIT_C107686 subClassOf NCIT_C1908 @default.
- NCIT_C107686 subClassOf NCIT_C1909 @default.
- NCIT_C107686 subClassOf NCIT_C2152 @default.
- NCIT_C107686 subClassOf NCIT_C2189 @default.
- NCIT_C107686 subClassOf NCIT_C274 @default.
- NCIT_C107686 subClassOf NCIT_C471 @default.