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- NCIT_C1083 IAO_0000115 "A bacterial enterotoxin with potential immunostimulatory activity. Staphylococcal enterotoxin A (SEA), a gram positive bacterial superantigen (SAg), is a potent stimulator of T-cell activation. SEA superantigen binds directly to class II major histocompatibility complex (MHC) molecules and to the V beta region of the T-cell receptor (TCR), leading to an amplified T-cell response. In response to SEA, both CD4+ and CD8+ cells proliferate, secrete cytokines, and demonstrate enhanced cytotoxic activity against a broad range of antigens. Vaccination with the SEA protein, administered by direct transfection into tumor cells, may elicit a non-specific cytotoxic T-cell (CTL) response and result in decreased tumor cell growth." @default.
- NCIT_C1083 NCIT_A32 NCIT_C1909 @default.
- NCIT_C1083 NCIT_NHC0 "C1083" @default.
- NCIT_C1083 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C1083 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C1083 NCIT_P108 "Staphylococcal Enterotoxin A" @default.
- NCIT_C1083 NCIT_P207 "C0059385" @default.
- NCIT_C1083 NCIT_P210 "37337-57-8" @default.
- NCIT_C1083 NCIT_P322 "CDISC" @default.
- NCIT_C1083 NCIT_P322 "GDC" @default.
- NCIT_C1083 NCIT_P325 "The biotoxin Staphylococcal enterotoxin A." @default.
- NCIT_C1083 NCIT_P329 "42927" @default.
- NCIT_C1083 NCIT_P330 "42927" @default.
- NCIT_C1083 NCIT_P366 "Staphylococcal_Enterotoxin_A" @default.
- NCIT_C1083 NCIT_P375 "Staphylococcal Enterotoxin A" @default.
- NCIT_C1083 NCIT_P399 "42927" @default.
- NCIT_C1083 normalizedInformationContent "100" @default.
- NCIT_C1083 referenceCount "1" @default.
- NCIT_C1083 hasExactSynonym "SEA" @default.
- NCIT_C1083 hasExactSynonym "STAPHYLOCOCCAL ENTEROTOXIN A" @default.
- NCIT_C1083 hasExactSynonym "Staphylococcal Enterotoxin A" @default.
- NCIT_C1083 inSubset NCIT_C128784 @default.
- NCIT_C1083 inSubset NCIT_C157711 @default.
- NCIT_C1083 inSubset NCIT_C157712 @default.
- NCIT_C1083 inSubset NCIT_C160930 @default.
- NCIT_C1083 inSubset NCIT_C176424 @default.
- NCIT_C1083 inSubset NCIT_C177537 @default.
- NCIT_C1083 inSubset NCIT_C181169 @default.
- NCIT_C1083 inSubset NCIT_C61410 @default.
- NCIT_C1083 inSubset NCIT_C66830 @default.
- NCIT_C1083 inSubset NCIT_C77526 @default.
- NCIT_C1083 type Class @default.
- NCIT_C1083 isDefinedBy ncit.owl @default.
- NCIT_C1083 label "Staphylococcal Enterotoxin A" @default.
- NCIT_C1083 subClassOf NCIT_C1083 @default.
- NCIT_C1083 subClassOf NCIT_C1456 @default.
- NCIT_C1083 subClassOf NCIT_C1908 @default.
- NCIT_C1083 subClassOf NCIT_C1932 @default.
- NCIT_C1083 subClassOf NCIT_C296 @default.
- NCIT_C1083 subClassOf NCIT_C470 @default.
- NCIT_C1083 subClassOf NCIT_C894 @default.