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- NCIT_C1084 IAO_0000115 "A bacterial enterotoxin with potential immunostimulatory activity. Staphylococcal enterotoxin B (SEB), a gram positive superantigen produced by Staphylococcus aureus, is a potent stimulator of T-cell activation. SEB binds directly to class II major histocompatibility complex (MHC) molecules and the V beta region of the T-cell receptor (TCR), leading to an amplified T-cell response. In response to SEB, both CD4+ and CD8+ cells proliferate, secrete cytokines and demonstrate enhanced cytotoxic activity against a broad range of antigens. Co-administration of SEB with interleukin-2 (IL-2) by direct injection into tumor cells, may induce clonal T-cell expansion and potentiate apoptosis of tumor cells, resulting in decreased tumor growth." @default.
- NCIT_C1084 NCIT_A32 NCIT_C1909 @default.
- NCIT_C1084 NCIT_NHC0 "C1084" @default.
- NCIT_C1084 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C1084 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C1084 NCIT_P108 "Staphylococcal Enterotoxin B" @default.
- NCIT_C1084 NCIT_P207 "C0059386" @default.
- NCIT_C1084 NCIT_P210 "39424-53-8" @default.
- NCIT_C1084 NCIT_P322 "CDISC" @default.
- NCIT_C1084 NCIT_P322 "GDC" @default.
- NCIT_C1084 NCIT_P325 "The biotoxin Staphylococcal enterotoxin B." @default.
- NCIT_C1084 NCIT_P329 "37929" @default.
- NCIT_C1084 NCIT_P330 "37929" @default.
- NCIT_C1084 NCIT_P366 "Staphylococcal_Enterotoxin_B" @default.
- NCIT_C1084 NCIT_P375 "Staphylococcal Enterotoxin B" @default.
- NCIT_C1084 NCIT_P399 "37929" @default.
- NCIT_C1084 normalizedInformationContent "95.413332725061409" @default.
- NCIT_C1084 referenceCount "2" @default.
- NCIT_C1084 hasExactSynonym "SEB" @default.
- NCIT_C1084 hasExactSynonym "STAPHYLOCOCCAL ENTEROTOXIN B" @default.
- NCIT_C1084 hasExactSynonym "Staphylococcal Enterotoxin B" @default.
- NCIT_C1084 inSubset NCIT_C128784 @default.
- NCIT_C1084 inSubset NCIT_C157711 @default.
- NCIT_C1084 inSubset NCIT_C157712 @default.
- NCIT_C1084 inSubset NCIT_C160930 @default.
- NCIT_C1084 inSubset NCIT_C176424 @default.
- NCIT_C1084 inSubset NCIT_C177537 @default.
- NCIT_C1084 inSubset NCIT_C181169 @default.
- NCIT_C1084 inSubset NCIT_C61410 @default.
- NCIT_C1084 inSubset NCIT_C66830 @default.
- NCIT_C1084 inSubset NCIT_C77526 @default.
- NCIT_C1084 type Class @default.
- NCIT_C1084 isDefinedBy ncit.owl @default.
- NCIT_C1084 label "Staphylococcal Enterotoxin B" @default.
- NCIT_C1084 subClassOf NCIT_C1084 @default.
- NCIT_C1084 subClassOf NCIT_C1456 @default.
- NCIT_C1084 subClassOf NCIT_C1908 @default.
- NCIT_C1084 subClassOf NCIT_C1932 @default.
- NCIT_C1084 subClassOf NCIT_C296 @default.
- NCIT_C1084 subClassOf NCIT_C470 @default.
- NCIT_C1084 subClassOf NCIT_C894 @default.