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- NCIT_C1087 IAO_0000115 "An indolequinone bioreductive prodrug and analog of mitomycin C with potential antineoplastic and radiosensitization activities. Apaziquone is converted to active metabolites in hypoxic cells by intracellular reductases, which are present in greater amounts in hypoxic tumor cells. The active metabolites alkylate DNA, resulting in apoptotic cell death. This agent displays selectivity activity towards both hypoxic solid tumors, which exhibits higher expression of cytochrome P450 reductase, and well-oxygenated malignant cells that overexpress the bioreductive enzyme NQO1 (NAD(P)H: quinone oxidoreductase). Apaziquone may selectively sensitize hypoxic tumor cells to radiocytotoxicity." @default.
- NCIT_C1087 NCIT_A32 NCIT_C1909 @default.
- NCIT_C1087 NCIT_NHC0 "C1087" @default.
- NCIT_C1087 NCIT_P106 "Organic Chemical" @default.
- NCIT_C1087 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C1087 NCIT_P107 "Apaziquone" @default.
- NCIT_C1087 NCIT_P108 "Apaziquone" @default.
- NCIT_C1087 NCIT_P175 "382456" @default.
- NCIT_C1087 NCIT_P207 "C0095568" @default.
- NCIT_C1087 NCIT_P210 "114560-48-4" @default.
- NCIT_C1087 NCIT_P319 "H464ZO600O" @default.
- NCIT_C1087 NCIT_P322 "CTRP" @default.
- NCIT_C1087 NCIT_P322 "FDA" @default.
- NCIT_C1087 NCIT_P322 "GDC" @default.
- NCIT_C1087 NCIT_P329 "42095" @default.
- NCIT_C1087 NCIT_P330 "42095" @default.
- NCIT_C1087 NCIT_P350 "C15H16N2O4" @default.
- NCIT_C1087 NCIT_P366 "EO9" @default.
- NCIT_C1087 NCIT_P375 "Apaziquone" @default.
- NCIT_C1087 NCIT_P399 "42095" @default.
- NCIT_C1087 normalizedInformationContent "100" @default.
- NCIT_C1087 referenceCount "1" @default.
- NCIT_C1087 hasExactSynonym "3-hydroxymethyl-5-aziridinyl-1-methyl-2-(1H-indole-4,7-dione) prop-beta-en-alpha-ol" @default.
- NCIT_C1087 hasExactSynonym "APAZIQUONE" @default.
- NCIT_C1087 hasExactSynonym "Apaziquone" @default.
- NCIT_C1087 hasExactSynonym "E O9" @default.
- NCIT_C1087 hasExactSynonym "EO9" @default.
- NCIT_C1087 hasExactSynonym "Eoquin" @default.
- NCIT_C1087 hasExactSynonym "Neoquin" @default.
- NCIT_C1087 hasExactSynonym "Qapzola" @default.
- NCIT_C1087 inSubset NCIT_C116977 @default.
- NCIT_C1087 inSubset NCIT_C116978 @default.
- NCIT_C1087 inSubset NCIT_C128784 @default.
- NCIT_C1087 inSubset NCIT_C157711 @default.
- NCIT_C1087 inSubset NCIT_C157712 @default.
- NCIT_C1087 inSubset NCIT_C176424 @default.
- NCIT_C1087 inSubset NCIT_C177537 @default.
- NCIT_C1087 inSubset NCIT_C63923 @default.
- NCIT_C1087 type Class @default.
- NCIT_C1087 isDefinedBy ncit.owl @default.
- NCIT_C1087 label "Apaziquone" @default.
- NCIT_C1087 subClassOf NCIT_C1087 @default.
- NCIT_C1087 subClassOf NCIT_C1590 @default.
- NCIT_C1087 subClassOf NCIT_C186664 @default.
- NCIT_C1087 subClassOf NCIT_C1908 @default.
- NCIT_C1087 subClassOf NCIT_C1909 @default.
- NCIT_C1087 subClassOf NCIT_C259 @default.
- NCIT_C1087 subClassOf NCIT_C274 @default.
- NCIT_C1087 subClassOf NCIT_C2842 @default.
- NCIT_C1087 subClassOf NCIT_C292 @default.
- NCIT_C1087 subClassOf NCIT_C663 @default.