Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C111038> ?p ?o ?g. }
Showing items 1 to 67 of
67
with 100 items per page.
- NCIT_C111038 IAO_0000115 "Autologous human CD8-positive T-lymphocytes transduced with a recombinant retroviral vector encoding a chimeric T cell receptor (chimeric antigen receptor or CAR) consisting of an anti-vascular endothelial growth factor receptor type 2 (VEGFR2) scFv (single chain variable fragment), linked to the transmembrane domain of human CD8alpha and coupled to the costimulatory signaling domains of both CD28 and 4-1BB (CD137), and the CD3 zeta chain of the T-cell receptor (TCR), with potential immunostimulating and antineoplastic activities. Autologous peripheral blood lymphocytes (PBLs) from a patient with VEGFR2-positive cancer are pulsed with a retroviral vector that encodes the CAR gene specific for VEGFR2. After expansion in culture and reintroduction into the patient, the anti-VEGFR2 CAR-gene engineered CD8+ lymphocytes express anti-VEGFR2-CAR on their cell surfaces and bind to the VEGFR2 antigen on tumor cell surfaces. Subsequently, VEGFR2-expressing tumor cells are lysed. VEGFR2, a receptor tyrosine kinase (RTK) overexpressed by a variety of cancer cell types, belongs to the VEGFR superfamily and plays key roles in tumor cell proliferation, survival, invasion and tumor angiogenesis. The co-stimulatory molecules are required for optimal T-cell activation." @default.
- NCIT_C111038 NCIT_A7 NCIT_C28496 @default.
- NCIT_C111038 NCIT_NHC0 "C111038" @default.
- NCIT_C111038 NCIT_P106 "Cell" @default.
- NCIT_C111038 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C111038 NCIT_P107 "Anti-VEGFR2-CAR Retroviral Vector-transduced Autologous T-lymphocytes" @default.
- NCIT_C111038 NCIT_P108 "Anti-VEGFR2-CAR Retroviral Vector-transduced Autologous T-lymphocytes" @default.
- NCIT_C111038 NCIT_P208 "CL453545" @default.
- NCIT_C111038 NCIT_P322 "CTRP" @default.
- NCIT_C111038 NCIT_P329 "751836" @default.
- NCIT_C111038 NCIT_P330 "751836" @default.
- NCIT_C111038 NCIT_P399 "751836" @default.
- NCIT_C111038 NCIT_R124 NCIT_C17828 @default.
- NCIT_C111038 NCIT_R124 NCIT_C17930 @default.
- NCIT_C111038 NCIT_R124 NCIT_C17937 @default.
- NCIT_C111038 NCIT_R124 NCIT_C18839 @default.
- NCIT_C111038 NCIT_R124 NCIT_C21124 @default.
- NCIT_C111038 NCIT_R124 NCIT_C45548 @default.
- NCIT_C111038 NCIT_R125 NCIT_C17828 @default.
- NCIT_C111038 NCIT_R125 NCIT_C17937 @default.
- NCIT_C111038 NCIT_R125 NCIT_C18095 @default.
- NCIT_C111038 NCIT_R125 NCIT_C18839 @default.
- NCIT_C111038 NCIT_R125 NCIT_C19053 @default.
- NCIT_C111038 NCIT_R125 NCIT_C21124 @default.
- NCIT_C111038 NCIT_R125 NCIT_C26280 @default.
- NCIT_C111038 NCIT_R125 NCIT_C40833 @default.
- NCIT_C111038 NCIT_R125 NCIT_C40912 @default.
- NCIT_C111038 NCIT_R72 NCIT_C104083 @default.
- NCIT_C111038 NCIT_R72 NCIT_C12219 @default.
- NCIT_C111038 NCIT_R72 NCIT_C12476 @default.
- NCIT_C111038 NCIT_R72 NCIT_C12508 @default.
- NCIT_C111038 NCIT_R72 NCIT_C12535 @default.
- NCIT_C111038 NCIT_R72 NCIT_C12542 @default.
- NCIT_C111038 NCIT_R72 NCIT_C12543 @default.
- NCIT_C111038 NCIT_R72 NCIT_C21599 @default.
- NCIT_C111038 NCIT_R72 NCIT_C32725 @default.
- NCIT_C111038 NCIT_R72 NCIT_C33061 @default.
- NCIT_C111038 NCIT_R72 NCIT_C38434 @default.
- NCIT_C111038 NCIT_R72 NCIT_C38439 @default.
- NCIT_C111038 NCIT_R72 NCIT_C39567 @default.
- NCIT_C111038 NCIT_R72 NCIT_C39568 @default.
- NCIT_C111038 normalizedInformationContent "100" @default.
- NCIT_C111038 referenceCount "1" @default.
- NCIT_C111038 hasExactSynonym "Anti-VEGFR2 Gene Engineered CD8+ Lymphocytes" @default.
- NCIT_C111038 hasExactSynonym "Anti-VEGFR2-CAR Retroviral Vector-transduced Autologous T-lymphocytes" @default.
- NCIT_C111038 inSubset NCIT_C116977 @default.
- NCIT_C111038 inSubset NCIT_C116978 @default.
- NCIT_C111038 inSubset NCIT_C128784 @default.
- NCIT_C111038 inSubset NCIT_C176424 @default.
- NCIT_C111038 type Class @default.
- NCIT_C111038 isDefinedBy ncit.owl @default.
- NCIT_C111038 label "Anti-VEGFR2-CAR Retroviral Vector-transduced Autologous T-lymphocytes" @default.
- NCIT_C111038 subClassOf NCIT_C111038 @default.
- NCIT_C111038 subClassOf NCIT_C129820 @default.
- NCIT_C111038 subClassOf NCIT_C129821 @default.
- NCIT_C111038 subClassOf NCIT_C129826 @default.
- NCIT_C111038 subClassOf NCIT_C137999 @default.
- NCIT_C111038 subClassOf NCIT_C142078 @default.
- NCIT_C111038 subClassOf NCIT_C154231 @default.
- NCIT_C111038 subClassOf NCIT_C1908 @default.
- NCIT_C111038 subClassOf NCIT_C1909 @default.
- NCIT_C111038 subClassOf NCIT_C1962 @default.
- NCIT_C111038 subClassOf NCIT_C200766 @default.
- NCIT_C111038 subClassOf NCIT_C274 @default.
- NCIT_C111038 subClassOf NCIT_C28681 @default.
- NCIT_C111038 subClassOf NCIT_C307 @default.
- NCIT_C111038 subClassOf NCIT_C308 @default.