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- NCIT_C111041 IAO_0000115 "Allogeneic T-lymphocytes derived from peripheral blood mononuclear cells (PBMC) transduced with a retroviral vector expressing a chimeric antigen receptor (CAR) consisting of both the light and heavy chain variable regions of anti-CD19 monoclonal antibody FMC63, coupled to the molecule CD28 and the signaling domain of the zeta chain of the T-cell receptor (TCR) (FMC63-28Z), with potential immunomodulating and antineoplastic activities. Upon transfusion, the anti-CD19-CAR FMC63-28Z retroviral vector-transduced allogeneic T lymphocytes specifically recognize and kill CD19-expressing tumor cells. CD19 antigen is a B-cell specific cell surface antigen, which is expressed in all B-cell lineage malignancies and normal B-cells." @default.
- NCIT_C111041 NCIT_A7 NCIT_C38894 @default.
- NCIT_C111041 NCIT_NHC0 "C111041" @default.
- NCIT_C111041 NCIT_P106 "Cell" @default.
- NCIT_C111041 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C111041 NCIT_P107 "Anti-CD19-CAR FMC63-28Z Retroviral Vector-transduced Allogeneic T-lymphocytes" @default.
- NCIT_C111041 NCIT_P108 "Anti-CD19-CAR FMC63-28Z Retroviral Vector-transduced Allogeneic T-lymphocytes" @default.
- NCIT_C111041 NCIT_P208 "CL453548" @default.
- NCIT_C111041 NCIT_P322 "CTRP" @default.
- NCIT_C111041 NCIT_P329 "751864" @default.
- NCIT_C111041 NCIT_P330 "751864" @default.
- NCIT_C111041 NCIT_P399 "751864" @default.
- NCIT_C111041 normalizedInformationContent "100" @default.
- NCIT_C111041 referenceCount "1" @default.
- NCIT_C111041 hasExactSynonym "Anti-CD19-CAR FMC63-28Z Retroviral Vector-transduced Allogeneic T-lymphocytes" @default.
- NCIT_C111041 hasExactSynonym "FMC63-28Z CAR-transduced Allogeneic T-lymphocytes" @default.
- NCIT_C111041 hasExactSynonym "MSGV1-FMC63-28Z Anti-CD19 CAR-transduced Allogeneic T-lymphocytes" @default.
- NCIT_C111041 inSubset NCIT_C116977 @default.
- NCIT_C111041 inSubset NCIT_C116978 @default.
- NCIT_C111041 inSubset NCIT_C128784 @default.
- NCIT_C111041 inSubset NCIT_C176424 @default.
- NCIT_C111041 type Class @default.
- NCIT_C111041 isDefinedBy ncit.owl @default.
- NCIT_C111041 label "Anti-CD19-CAR FMC63-28Z Retroviral Vector-transduced Allogeneic T-lymphocytes" @default.
- NCIT_C111041 subClassOf NCIT_C111041 @default.
- NCIT_C111041 subClassOf NCIT_C129820 @default.
- NCIT_C111041 subClassOf NCIT_C129821 @default.
- NCIT_C111041 subClassOf NCIT_C129826 @default.
- NCIT_C111041 subClassOf NCIT_C137999 @default.
- NCIT_C111041 subClassOf NCIT_C142078 @default.
- NCIT_C111041 subClassOf NCIT_C154231 @default.
- NCIT_C111041 subClassOf NCIT_C176018 @default.
- NCIT_C111041 subClassOf NCIT_C1908 @default.
- NCIT_C111041 subClassOf NCIT_C1909 @default.
- NCIT_C111041 subClassOf NCIT_C1962 @default.
- NCIT_C111041 subClassOf NCIT_C200765 @default.
- NCIT_C111041 subClassOf NCIT_C274 @default.
- NCIT_C111041 subClassOf NCIT_C28676 @default.
- NCIT_C111041 subClassOf NCIT_C307 @default.
- NCIT_C111041 subClassOf NCIT_C308 @default.