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- NCIT_C111042 IAO_0000115 "An orally bioavailable, small molecule inhibitor of signaling transducer and activator 3 (STAT3), with potential antineoplastic and immunomodulatory activities. Upon administration, STAT3 inhibitor WP1066 blocks the intranuclear translocation of p-STAT, thereby suppressing STAT3 signaling and decreasing the levels of downstream products including c-Myc. Additionally, WP1066 may upregulate costimulatory molecules including CD80 and CD86 on human microglia, and reverse glioma cancer stem cell (gCSC)-mediated innate and adaptive immune suppression allowing for the restoration of antitumor effector immune responses. The STAT3 pathway is overly active in many cancer types and is implicated in CSC-mediated growth, recurrence and resistance to conventional chemotherapies." @default.
- NCIT_C111042 NCIT_A32 NCIT_C1909 @default.
- NCIT_C111042 NCIT_A7 NCIT_C28664 @default.
- NCIT_C111042 NCIT_NHC0 "C111042" @default.
- NCIT_C111042 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C111042 NCIT_P107 "STAT3 Inhibitor WP1066" @default.
- NCIT_C111042 NCIT_P108 "STAT3 Inhibitor WP1066" @default.
- NCIT_C111042 NCIT_P207 "C1957161" @default.
- NCIT_C111042 NCIT_P210 "857064-38-1" @default.
- NCIT_C111042 NCIT_P319 "63V8AIE65T" @default.
- NCIT_C111042 NCIT_P322 "CTRP" @default.
- NCIT_C111042 NCIT_P322 "FDA" @default.
- NCIT_C111042 NCIT_P322 "GDC" @default.
- NCIT_C111042 NCIT_P329 "751888" @default.
- NCIT_C111042 NCIT_P330 "751888" @default.
- NCIT_C111042 NCIT_P375 "STAT3 Inhibitor WP1066" @default.
- NCIT_C111042 NCIT_P399 "751888" @default.
- NCIT_C111042 normalizedInformationContent "100" @default.
- NCIT_C111042 referenceCount "1" @default.
- NCIT_C111042 hasExactSynonym "(S,E)-3-(6-Bromopyridin-2-yl)-2-cyano-N-(1-phenylethyl)acrylamide" @default.
- NCIT_C111042 hasExactSynonym "STAT3 Inhibitor WP1066" @default.
- NCIT_C111042 hasExactSynonym "WP 1066" @default.
- NCIT_C111042 hasExactSynonym "WP-1066" @default.
- NCIT_C111042 hasExactSynonym "WP1066" @default.
- NCIT_C111042 inSubset NCIT_C116977 @default.
- NCIT_C111042 inSubset NCIT_C116978 @default.
- NCIT_C111042 inSubset NCIT_C128784 @default.
- NCIT_C111042 inSubset NCIT_C157711 @default.
- NCIT_C111042 inSubset NCIT_C157712 @default.
- NCIT_C111042 inSubset NCIT_C176424 @default.
- NCIT_C111042 inSubset NCIT_C177537 @default.
- NCIT_C111042 inSubset NCIT_C63923 @default.
- NCIT_C111042 type Class @default.
- NCIT_C111042 isDefinedBy ncit.owl @default.
- NCIT_C111042 label "STAT3 Inhibitor WP1066" @default.
- NCIT_C111042 subClassOf NCIT_C111042 @default.
- NCIT_C111042 subClassOf NCIT_C1908 @default.
- NCIT_C111042 subClassOf NCIT_C1909 @default.
- NCIT_C111042 subClassOf NCIT_C2189 @default.
- NCIT_C111042 subClassOf NCIT_C274 @default.