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- NCIT_C1112 IAO_0000115 "A benzoquinone antineoplastic antibiotic isolated from the bacterium Streptomyces hygroscopicus. Geldanamycin binds to and inhibits the cytosolic chaperone functions of heat shock protein 90 (HSP90). HSP90 maintains the stability and functional shape of many oncogenic signaling proteins; the inhibition of HSP90 promotes the proteasomal degradation of oncogenic signaling proteins that may be over-expressed or overactive in tumor cells. (NCI04)" @default.
- NCIT_C1112 NCIT_A32 NCIT_C1909 @default.
- NCIT_C1112 NCIT_NHC0 "C1112" @default.
- NCIT_C1112 NCIT_P106 "Antibiotic" @default.
- NCIT_C1112 NCIT_P106 "Organic Chemical" @default.
- NCIT_C1112 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C1112 NCIT_P108 "Geldanamycin" @default.
- NCIT_C1112 NCIT_P175 "122750" @default.
- NCIT_C1112 NCIT_P175 "212518" @default.
- NCIT_C1112 NCIT_P207 "C0061179" @default.
- NCIT_C1112 NCIT_P210 "30562-34-6" @default.
- NCIT_C1112 NCIT_P319 "Z3K3VJ16KU" @default.
- NCIT_C1112 NCIT_P322 "FDA" @default.
- NCIT_C1112 NCIT_P322 "GDC" @default.
- NCIT_C1112 NCIT_P366 "Geldanamycin" @default.
- NCIT_C1112 NCIT_P368 "CHEBI:5292" @default.
- NCIT_C1112 NCIT_P375 "Geldanamycin" @default.
- NCIT_C1112 normalizedInformationContent "100" @default.
- NCIT_C1112 referenceCount "1" @default.
- NCIT_C1112 hasExactSynonym "Antibiotic (U-29,135)" @default.
- NCIT_C1112 hasExactSynonym "Antibiotic U 29135" @default.
- NCIT_C1112 hasExactSynonym "GELDANAMYCIN" @default.
- NCIT_C1112 hasExactSynonym "Geldanamycin" @default.
- NCIT_C1112 inSubset NCIT_C128784 @default.
- NCIT_C1112 inSubset NCIT_C157711 @default.
- NCIT_C1112 inSubset NCIT_C157712 @default.
- NCIT_C1112 inSubset NCIT_C177537 @default.
- NCIT_C1112 inSubset NCIT_C63923 @default.
- NCIT_C1112 type Class @default.
- NCIT_C1112 isDefinedBy ncit.owl @default.
- NCIT_C1112 label "Geldanamycin" @default.
- NCIT_C1112 subClassOf NCIT_C1003 @default.
- NCIT_C1112 subClassOf NCIT_C1112 @default.
- NCIT_C1112 subClassOf NCIT_C129824 @default.
- NCIT_C1112 subClassOf NCIT_C186664 @default.
- NCIT_C1112 subClassOf NCIT_C1908 @default.
- NCIT_C1112 subClassOf NCIT_C1909 @default.
- NCIT_C1112 subClassOf NCIT_C2189 @default.
- NCIT_C1112 subClassOf NCIT_C259 @default.
- NCIT_C1112 subClassOf NCIT_C274 @default.
- NCIT_C1112 subClassOf NCIT_C74526 @default.