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- NCIT_C111566 IAO_0000115 "A radioconjugate comprised of the orally available reversible 20S proteasome inhibitor ixazomib and labeled with the isotope carbon C 14. Upon administration, the ixazomib moiety hydrolyzes and generates its active form, MLN2238, which inhibits the activity of the 20S catalytic core subunit of the proteasome. This blocks the targeted proteolysis normally performed by the proteasome, which results in an accumulation of unwanted or misfolded proteins. The accumulation of protein may disrupt various cell signaling pathways, induce apoptosis, and inhibit tumor growth. In addition, this agent targets tumor suppressor microRNA-33b (miR-33b). Labeling with the radioactive tracer carbon C 14 allows for evaluation of ixazomib's absorption, distribution, metabolism and excretion (ADME)." @default.
- NCIT_C111566 NCIT_NHC0 "C111566" @default.
- NCIT_C111566 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C111566 NCIT_P107 "Carbon C 14-labeled Ixazomib" @default.
- NCIT_C111566 NCIT_P108 "Carbon C 14-labeled Ixazomib" @default.
- NCIT_C111566 NCIT_P208 "CL453974" @default.
- NCIT_C111566 NCIT_P322 "CTRP" @default.
- NCIT_C111566 NCIT_P329 "751947" @default.
- NCIT_C111566 NCIT_P330 "751947" @default.
- NCIT_C111566 NCIT_P399 "751947" @default.
- NCIT_C111566 normalizedInformationContent "100" @default.
- NCIT_C111566 referenceCount "1" @default.
- NCIT_C111566 hasExactSynonym "Carbon C 14-labeled Ixazomib" @default.
- NCIT_C111566 hasExactSynonym "[14C]-1,4-(R,S)-(carboxymethyl)-2-((R)-1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutyl)-6-oxo-1,3,2-dioxaborinane-4-carboxylic Acid" @default.
- NCIT_C111566 hasExactSynonym "[14C]-Ixazomib" @default.
- NCIT_C111566 hasExactSynonym "[14C]-MLN9708" @default.
- NCIT_C111566 inSubset NCIT_C116977 @default.
- NCIT_C111566 inSubset NCIT_C116978 @default.
- NCIT_C111566 inSubset NCIT_C176424 @default.
- NCIT_C111566 type Class @default.
- NCIT_C111566 isDefinedBy ncit.owl @default.
- NCIT_C111566 label "Carbon C 14-labeled Ixazomib" @default.
- NCIT_C111566 subClassOf NCIT_C111566 @default.
- NCIT_C111566 subClassOf NCIT_C1446 @default.
- NCIT_C111566 subClassOf NCIT_C1908 @default.
- NCIT_C111566 subClassOf NCIT_C1909 @default.
- NCIT_C111566 subClassOf NCIT_C2124 @default.