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- NCIT_C111569 IAO_0000115 "An orally available inhibitor of maternal embryonic leucine zipper kinase (MELK) with potential antineoplastic activity. Upon administration, OTS167 binds to MELK, which prevents both MELK phosphorylation and activation; thus inhibiting the phosphorylation of downstream MELK substrates. This may lead to an inhibition of both cell proliferation and survival in MELK-expressing tumor cells. MELK, a serine/threonine kinase, is involved in cancer cell survival, invasiveness and cancer-stem cell formation and maintenance; it is highly upregulated in various types of cancer cells and absent in normal, healthy cells." @default.
- NCIT_C111569 NCIT_A32 NCIT_C1909 @default.
- NCIT_C111569 NCIT_A7 NCIT_C134700 @default.
- NCIT_C111569 NCIT_NHC0 "C111569" @default.
- NCIT_C111569 NCIT_P106 "Organic Chemical" @default.
- NCIT_C111569 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C111569 NCIT_P107 "MELK Inhibitor OTS167" @default.
- NCIT_C111569 NCIT_P108 "MELK Inhibitor OTS167" @default.
- NCIT_C111569 NCIT_P208 "CL453977" @default.
- NCIT_C111569 NCIT_P210 "1431697-89-0" @default.
- NCIT_C111569 NCIT_P319 "VY778IXU5T" @default.
- NCIT_C111569 NCIT_P322 "CTRP" @default.
- NCIT_C111569 NCIT_P322 "FDA" @default.
- NCIT_C111569 NCIT_P322 "GDC" @default.
- NCIT_C111569 NCIT_P329 "751983" @default.
- NCIT_C111569 NCIT_P330 "751983" @default.
- NCIT_C111569 NCIT_P375 "MELK Inhibitor OTS167" @default.
- NCIT_C111569 NCIT_P399 "751983" @default.
- NCIT_C111569 normalizedInformationContent "100" @default.
- NCIT_C111569 referenceCount "1" @default.
- NCIT_C111569 hasExactSynonym "MELK Inhibitor OTS167" @default.
- NCIT_C111569 hasExactSynonym "OTS-167" @default.
- NCIT_C111569 hasExactSynonym "OTS167" @default.
- NCIT_C111569 inSubset NCIT_C116977 @default.
- NCIT_C111569 inSubset NCIT_C116978 @default.
- NCIT_C111569 inSubset NCIT_C128784 @default.
- NCIT_C111569 inSubset NCIT_C157711 @default.
- NCIT_C111569 inSubset NCIT_C157712 @default.
- NCIT_C111569 inSubset NCIT_C176424 @default.
- NCIT_C111569 inSubset NCIT_C177537 @default.
- NCIT_C111569 inSubset NCIT_C63923 @default.
- NCIT_C111569 type Class @default.
- NCIT_C111569 isDefinedBy ncit.owl @default.
- NCIT_C111569 label "MELK Inhibitor OTS167" @default.
- NCIT_C111569 subClassOf NCIT_C111569 @default.
- NCIT_C111569 subClassOf NCIT_C1404 @default.
- NCIT_C111569 subClassOf NCIT_C1908 @default.
- NCIT_C111569 subClassOf NCIT_C1909 @default.
- NCIT_C111569 subClassOf NCIT_C471 @default.
- NCIT_C111569 subClassOf NCIT_C61074 @default.