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- NCIT_C111570 IAO_0000115 "A lipid-based nanosomal formulation of the poorly soluble, semi-synthetic, second-generation taxane docetaxel, with potential antineoplastic activity. Upon intravenous injection, docetaxel binds to and stabilizes tubulin, which inhibits microtubule disassembly and results in both cell cycle arrest at the G2/M phase and cell death. This liposomal formulation solubilizes docetaxel without the use of toxic solvents, such as polysorbate 80. This permits the administration of larger doses of docetaxel and improves the drug's safety profile by avoiding solvent-associated toxicities, such as hypersensitivity reactions and neurotoxicity. In addition, the nanosomal lipid-based delivery of docetaxel improves drug penetration into tumors and decreases drug clearance, all of which prolong the duration of docetaxel's therapeutic effects." @default.
- NCIT_C111570 NCIT_A32 NCIT_C1909 @default.
- NCIT_C111570 NCIT_NHC0 "C111570" @default.
- NCIT_C111570 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C111570 NCIT_P107 "Nanosomal Docetaxel Lipid Suspension" @default.
- NCIT_C111570 NCIT_P108 "Nanosomal Docetaxel Lipid Suspension" @default.
- NCIT_C111570 NCIT_P208 "CL453978" @default.
- NCIT_C111570 NCIT_P322 "CTRP" @default.
- NCIT_C111570 NCIT_P322 "GDC" @default.
- NCIT_C111570 NCIT_P329 "752055" @default.
- NCIT_C111570 NCIT_P330 "752055" @default.
- NCIT_C111570 NCIT_P375 "Nanosomal Docetaxel Lipid Suspension" @default.
- NCIT_C111570 NCIT_P399 "752055" @default.
- NCIT_C111570 NCIT_R124 NCIT_C17828 @default.
- NCIT_C111570 NCIT_R124 NCIT_C20480 @default.
- NCIT_C111570 NCIT_R124 NCIT_C40795 @default.
- NCIT_C111570 NCIT_R124 NCIT_C40798 @default.
- NCIT_C111570 normalizedInformationContent "100" @default.
- NCIT_C111570 referenceCount "1" @default.
- NCIT_C111570 hasExactSynonym "DTX-LNS" @default.
- NCIT_C111570 hasExactSynonym "NDLS" @default.
- NCIT_C111570 hasExactSynonym "Nanosomal Docetaxel Lipid Suspension" @default.
- NCIT_C111570 inSubset NCIT_C116977 @default.
- NCIT_C111570 inSubset NCIT_C116978 @default.
- NCIT_C111570 inSubset NCIT_C128784 @default.
- NCIT_C111570 inSubset NCIT_C157711 @default.
- NCIT_C111570 inSubset NCIT_C157712 @default.
- NCIT_C111570 inSubset NCIT_C176424 @default.
- NCIT_C111570 inSubset NCIT_C177537 @default.
- NCIT_C111570 type Class @default.
- NCIT_C111570 isDefinedBy ncit.owl @default.
- NCIT_C111570 label "Nanosomal Docetaxel Lipid Suspension" @default.
- NCIT_C111570 subClassOf NCIT_C111570 @default.
- NCIT_C111570 subClassOf NCIT_C186664 @default.
- NCIT_C111570 subClassOf NCIT_C1908 @default.
- NCIT_C111570 subClassOf NCIT_C1909 @default.
- NCIT_C111570 subClassOf NCIT_C25974 @default.
- NCIT_C111570 subClassOf NCIT_C273 @default.
- NCIT_C111570 subClassOf NCIT_C274 @default.
- NCIT_C111570 subClassOf NCIT_C67437 @default.