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- NCIT_C111571 IAO_0000115 "A preparation of allogeneic umbilical cord blood (UCB)-derived hematopoietic stem and progenitor cells (HSPCs) expanded in culture with the stimulatory cytokines stem cell factor (SCF; Kit ligand; mast cell growth factor; MGF), FMS-like tyrosine kinase 3 ligand (Flt3L), interleukin 6 (IL-6), and thrombopoietin, in the presence of an aryl hydrocarbon receptor (AHR) antagonist LHD221 (StemRegenin-1; SR-1), with potential to improve hematopoietic recovery following myeloablative conditioning. Upon administration of Spanlecortemlocel, these cells increase and restore the number of HSPCs, which may prevent or decrease the risk of infection and other complications of chemotherapy-induced neutropenia (CIN) or cord blood transplantation. LHD221, an AHR antagonist facilitates the expansion of CD34-positive hematopoietic progenitors and impedes HSPC differentiation during cytokine-driven expansion in culture." @default.
- NCIT_C111571 NCIT_A32 NCIT_C1909 @default.
- NCIT_C111571 NCIT_NHC0 "C111571" @default.
- NCIT_C111571 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C111571 NCIT_P107 "Spanlecortemlocel" @default.
- NCIT_C111571 NCIT_P108 "Spanlecortemlocel" @default.
- NCIT_C111571 NCIT_P208 "CL453979" @default.
- NCIT_C111571 NCIT_P319 "D8O38M043D" @default.
- NCIT_C111571 NCIT_P322 "CTRP" @default.
- NCIT_C111571 NCIT_P322 "FDA" @default.
- NCIT_C111571 NCIT_P322 "GDC" @default.
- NCIT_C111571 NCIT_P329 "752075" @default.
- NCIT_C111571 NCIT_P330 "752075" @default.
- NCIT_C111571 NCIT_P375 "Spanlecortemlocel" @default.
- NCIT_C111571 NCIT_P399 "752075" @default.
- NCIT_C111571 normalizedInformationContent "100" @default.
- NCIT_C111571 referenceCount "1" @default.
- NCIT_C111571 hasExactSynonym "Allogeneic UCB-derived HSPCs MGTA 456" @default.
- NCIT_C111571 hasExactSynonym "Allogeneic Umbilical Cord Blood-derived Hematopoietic Stem and Progenitor Cells MGTA-456" @default.
- NCIT_C111571 hasExactSynonym "Expanded Umbilical Cord Blood Product HSC835" @default.
- NCIT_C111571 hasExactSynonym "HSC 835" @default.
- NCIT_C111571 hasExactSynonym "HSC835" @default.
- NCIT_C111571 hasExactSynonym "MGTA 456" @default.
- NCIT_C111571 hasExactSynonym "MGTA-456" @default.
- NCIT_C111571 hasExactSynonym "SPANLECORTEMLOCEL" @default.
- NCIT_C111571 hasExactSynonym "Spanlecortemlocel" @default.
- NCIT_C111571 inSubset NCIT_C116977 @default.
- NCIT_C111571 inSubset NCIT_C116978 @default.
- NCIT_C111571 inSubset NCIT_C157711 @default.
- NCIT_C111571 inSubset NCIT_C157712 @default.
- NCIT_C111571 inSubset NCIT_C176424 @default.
- NCIT_C111571 inSubset NCIT_C177537 @default.
- NCIT_C111571 inSubset NCIT_C63923 @default.
- NCIT_C111571 type Class @default.
- NCIT_C111571 isDefinedBy ncit.owl @default.
- NCIT_C111571 label "Spanlecortemlocel" @default.
- NCIT_C111571 subClassOf NCIT_C111571 @default.
- NCIT_C111571 subClassOf NCIT_C142078 @default.
- NCIT_C111571 subClassOf NCIT_C1908 @default.
- NCIT_C111571 subClassOf NCIT_C1909 @default.
- NCIT_C111571 subClassOf NCIT_C201554 @default.
- NCIT_C111571 subClassOf NCIT_C307 @default.
- NCIT_C111571 subClassOf NCIT_C308 @default.