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- NCIT_C111572 IAO_0000115 "A radioconjugate composed of the platinum agent oxaliplatin labeled with the isotope carbon C 14, that can be used to predict the response to oxaliplatin therapy using accelerator mass spectrometry (AMS). Upon intravenous administration of a microdose of carbon C 14 oxaliplatin, the oxaliplatin moiety covalently links to DNA and forms mono- and di-DNA adducts. The platinum-DNA adduct formation can be measured through quantification of C14-labeled drug-DNA adducts by using AMS. By measuring the microdose-induced DNA damage, the response to oxaliplatin-based chemotherapy can be assessed and predicted. Measurements that indicate either low drug-DNA adduct formation or increased DNA repair (C14 removal from DNA) are correlated with increased resistance to platinum-based chemotherapeutics." @default.
- NCIT_C111572 NCIT_NHC0 "C111572" @default.
- NCIT_C111572 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C111572 NCIT_P107 "Carbon C 14 Oxaliplatin" @default.
- NCIT_C111572 NCIT_P108 "Carbon C 14 Oxaliplatin" @default.
- NCIT_C111572 NCIT_P208 "CL453980" @default.
- NCIT_C111572 NCIT_P322 "CTRP" @default.
- NCIT_C111572 NCIT_P329 "752239" @default.
- NCIT_C111572 NCIT_P330 "752239" @default.
- NCIT_C111572 NCIT_P399 "752239" @default.
- NCIT_C111572 normalizedInformationContent "100" @default.
- NCIT_C111572 referenceCount "1" @default.
- NCIT_C111572 hasExactSynonym "Carbon C 14 Oxaliplatin" @default.
- NCIT_C111572 hasExactSynonym "[14C] Oxaliplatin" @default.
- NCIT_C111572 inSubset NCIT_C116977 @default.
- NCIT_C111572 inSubset NCIT_C116978 @default.
- NCIT_C111572 inSubset NCIT_C176424 @default.
- NCIT_C111572 type Class @default.
- NCIT_C111572 isDefinedBy ncit.owl @default.
- NCIT_C111572 label "Carbon C 14 Oxaliplatin" @default.
- NCIT_C111572 subClassOf NCIT_C111572 @default.
- NCIT_C111572 subClassOf NCIT_C1446 @default.
- NCIT_C111572 subClassOf NCIT_C1908 @default.
- NCIT_C111572 subClassOf NCIT_C1909 @default.
- NCIT_C111572 subClassOf NCIT_C2124 @default.