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- NCIT_C111757 IAO_0000115 "An oral suspension containing the thiopurine-derivative antimetabolite 6-mercaptopurine, with potential antineoplastic activity. Upon oral administration, mercaptopurine is metabolized by hypoxanthine-guanine phosphoribosyltransferase (HGPRTase) to its active metabolite 6-thioinosine monophosphate (TIMP); TIMP inhibits nucleotide interconversions and de novo purine ribonucleotide synthesis, which both blocks the formation of purine nucleotides and inhibits DNA synthesis. This agent is also incorporated into DNA in the form of deoxythioguanosine, which results in the disruption of DNA replication. By blocking DNA synthesis and replication, cancer cells are unable to proliferate. Compared to the tablet formulation, the liquid is easier to swallow and offers more flexibility and accuracy in dosing, which is beneficial for use in pediatric patients." @default.
- NCIT_C111757 NCIT_A32 NCIT_C1909 @default.
- NCIT_C111757 NCIT_NHC0 "C111757" @default.
- NCIT_C111757 NCIT_P106 "Nucleic Acid, Nucleoside, or Nucleotide" @default.
- NCIT_C111757 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C111757 NCIT_P108 "Mercaptopurine Oral Suspension" @default.
- NCIT_C111757 NCIT_P207 "C3820263" @default.
- NCIT_C111757 NCIT_P302 "acute lymphoblastic leukemia (ALL)" @default.
- NCIT_C111757 NCIT_P322 "GDC" @default.
- NCIT_C111757 NCIT_P329 "752956" @default.
- NCIT_C111757 NCIT_P330 "752956" @default.
- NCIT_C111757 NCIT_P375 "Mercaptopurine Oral Suspension" @default.
- NCIT_C111757 NCIT_P399 "752956" @default.
- NCIT_C111757 normalizedInformationContent "100" @default.
- NCIT_C111757 referenceCount "1" @default.
- NCIT_C111757 hasExactSynonym "6-MP Oral Suspension" @default.
- NCIT_C111757 hasExactSynonym "Mercaptopurine Oral Suspension" @default.
- NCIT_C111757 hasExactSynonym "Purixan" @default.
- NCIT_C111757 hasExactSynonym "Xaluprine" @default.
- NCIT_C111757 inSubset NCIT_C128784 @default.
- NCIT_C111757 inSubset NCIT_C157711 @default.
- NCIT_C111757 inSubset NCIT_C157712 @default.
- NCIT_C111757 inSubset NCIT_C176424 @default.
- NCIT_C111757 inSubset NCIT_C177537 @default.
- NCIT_C111757 type Class @default.
- NCIT_C111757 isDefinedBy ncit.owl @default.
- NCIT_C111757 label "Mercaptopurine Oral Suspension" @default.
- NCIT_C111757 subClassOf NCIT_C111757 @default.
- NCIT_C111757 subClassOf NCIT_C1556 @default.
- NCIT_C111757 subClassOf NCIT_C186664 @default.
- NCIT_C111757 subClassOf NCIT_C1908 @default.
- NCIT_C111757 subClassOf NCIT_C1909 @default.
- NCIT_C111757 subClassOf NCIT_C272 @default.
- NCIT_C111757 subClassOf NCIT_C274 @default.