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- NCIT_C111758 IAO_0000115 "An orally bioavailable inhibitor of mitochondrial oxidative phosphorylation with potential antineoplastic activity. Upon administration, ATR-101 inhibits the activity of F1F0-ATP synthase, elevates the mitochondrial membrane potential and depletes ATP in adrenocortical cells. The mitochondrial dysfunction caused by the release of reactive oxygen and triggered cytochrome c release leads to caspase-mediated cell death. ATR-101 may be useful in treating certain types of adrenocortical carcinoma." @default.
- NCIT_C111758 NCIT_A32 NCIT_C1909 @default.
- NCIT_C111758 NCIT_NHC0 "C111758" @default.
- NCIT_C111758 NCIT_P106 "Nucleic Acid, Nucleoside, or Nucleotide" @default.
- NCIT_C111758 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C111758 NCIT_P107 "Mitochondrial Oxidative Phosphorylation Inhibitor ATR-101" @default.
- NCIT_C111758 NCIT_P108 "Mitochondrial Oxidative Phosphorylation Inhibitor ATR-101" @default.
- NCIT_C111758 NCIT_P208 "CL454145" @default.
- NCIT_C111758 NCIT_P322 "CTRP" @default.
- NCIT_C111758 NCIT_P322 "GDC" @default.
- NCIT_C111758 NCIT_P329 "753012" @default.
- NCIT_C111758 NCIT_P330 "753012" @default.
- NCIT_C111758 NCIT_P375 "Mitochondrial Oxidative Phosphorylation Inhibitor ATR-101" @default.
- NCIT_C111758 NCIT_P399 "753012" @default.
- NCIT_C111758 normalizedInformationContent "100" @default.
- NCIT_C111758 referenceCount "1" @default.
- NCIT_C111758 hasExactSynonym "Mitochondrial Oxidative Phosphorylation Inhibitor ATR-101" @default.
- NCIT_C111758 inSubset NCIT_C116977 @default.
- NCIT_C111758 inSubset NCIT_C116978 @default.
- NCIT_C111758 inSubset NCIT_C128784 @default.
- NCIT_C111758 inSubset NCIT_C157711 @default.
- NCIT_C111758 inSubset NCIT_C157712 @default.
- NCIT_C111758 inSubset NCIT_C176424 @default.
- NCIT_C111758 inSubset NCIT_C177537 @default.
- NCIT_C111758 type Class @default.
- NCIT_C111758 isDefinedBy ncit.owl @default.
- NCIT_C111758 label "Mitochondrial Oxidative Phosphorylation Inhibitor ATR-101" @default.
- NCIT_C111758 subClassOf NCIT_C111758 @default.
- NCIT_C111758 subClassOf NCIT_C177285 @default.
- NCIT_C111758 subClassOf NCIT_C177298 @default.
- NCIT_C111758 subClassOf NCIT_C1908 @default.
- NCIT_C111758 subClassOf NCIT_C1909 @default.
- NCIT_C111758 subClassOf NCIT_C274 @default.