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- NCIT_C111759 IAO_0000115 "A preparation of cells, which consists of autologous marrow infiltrating lymphocytes (MILs), that are manipulated in vitro, with potential antitumor and immune stimulating activities. MILs are harvested from autologous bone marrow from multiple myeloma patients and, in vitro, are exposed to and activated by anti-CD3/anti-CD28 monoclonal antibodies covalently attached to super-paramagnetic microbeads. After removal of the beads and expansion of the cells in culture, the activated MILs (aMILs) are re-introduced into the patient. The aMILs possess enhanced myeloma specificity, and are able to infiltrate the tumor microenvironment and initiate tumor cell lysis. CD3 and CD28, co-stimulatory molecules expressed on the surface of T-lymphocytes, play a key role in the activation of T-cells." @default.
- NCIT_C111759 NCIT_NHC0 "C111759" @default.
- NCIT_C111759 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C111759 NCIT_P107 "Activated Marrow Infiltrating Lymphocytes" @default.
- NCIT_C111759 NCIT_P108 "Activated Marrow Infiltrating Lymphocytes" @default.
- NCIT_C111759 NCIT_P208 "CL454146" @default.
- NCIT_C111759 NCIT_P322 "CTRP" @default.
- NCIT_C111759 NCIT_P329 "753013" @default.
- NCIT_C111759 NCIT_P330 "753013" @default.
- NCIT_C111759 NCIT_P399 "753013" @default.
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- NCIT_C111759 normalizedInformationContent "100" @default.
- NCIT_C111759 referenceCount "1" @default.
- NCIT_C111759 hasExactSynonym "Activated Marrow Infiltrating Lymphocytes" @default.
- NCIT_C111759 hasExactSynonym "aMIL" @default.
- NCIT_C111759 inSubset NCIT_C116977 @default.
- NCIT_C111759 inSubset NCIT_C116978 @default.
- NCIT_C111759 inSubset NCIT_C128784 @default.
- NCIT_C111759 inSubset NCIT_C176424 @default.
- NCIT_C111759 type Class @default.
- NCIT_C111759 isDefinedBy ncit.owl @default.
- NCIT_C111759 label "Activated Marrow Infiltrating Lymphocytes" @default.
- NCIT_C111759 subClassOf NCIT_C111759 @default.
- NCIT_C111759 subClassOf NCIT_C129820 @default.
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- NCIT_C111759 subClassOf NCIT_C142078 @default.
- NCIT_C111759 subClassOf NCIT_C1908 @default.
- NCIT_C111759 subClassOf NCIT_C1909 @default.
- NCIT_C111759 subClassOf NCIT_C274 @default.
- NCIT_C111759 subClassOf NCIT_C28681 @default.
- NCIT_C111759 subClassOf NCIT_C307 @default.
- NCIT_C111759 subClassOf NCIT_C308 @default.